Database of 2233 Experimentally Validated Allergens

Data for Der p 1
WHO/IUIS recognized Allergen

1  1  1  1  1  1  1  1  1 
Completeness Index: Denotes availibility of data for the allergen in Binary format
1: data available
0: data not available
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AllerBase IDAB_A_00709Allergen NameDer p 1
Source OrganismDermatophagoides pteronyssinus (European house dust mite)KingdomAnimal
Biological Function/RoleCysteine proteaseMode of ExposureInhalation

Assays/Methods used for Experimental Characterization (Read More)

  :  Data Available    : Data not Available

Biological assay / test IgE assay / test Physicochemical test Cell-based assay
Basophil/Mast cell/Histamine Test  (Reference/s)EAST  (Reference/s)Chromatography  (Reference/s)Lymphocyte proliferation assay  (Reference/s)
Bronchial Test  (Reference/s)ELISA  (Reference/s)Isoelectrofocusing 
Conjunctival Test Crossed immunoelectrophoresis Mass spectrometry (MS)  (Reference/s)
Nasal Test  (Reference/s)Fluorescence Immunoassay  (Reference/s)N-terminal sequencing/sequence analysis  (Reference/s)
Oral Test Immunochemiluminescent assay  (Reference/s)
Passive Cutaneous Anaphylaxis (PCA) ImmunoCAP Test  (Reference/s)
Skin Test  (Reference/s)Microarray  (Reference/s)
Radio Immunoassay  (Reference/s)
RAST  (Reference/s)
Western/Immunoblot  (Reference/s)

Isoallergen/Variant for Der p 1:Available

Isoallergen/Variant Common Name GenBank Nucleotide NCBI Protein (GenPept) UniProtKB RCSB-PDB (Click on the PDB id to view structure) ETR (Evolutionary Trace analysis Report)
Der p 1.0101Peptidase 1
U11695.1  (View Sequence)AAB60215.1  (View Sequence)P08176  (View Sequence)
3RVW 3RVX 3F5V 
4PP1 4PP2 
3rvw  3rvx  3f5v  
4pp1  4pp2  
Der p 1.0102Peptidase 1U11695.1  (View Sequence)AAB60215.1  (View Sequence)P08176  (View Sequence)
--
Der p 1.0103Peptidase 1U11695.1  (View Sequence)AAB60215.1  (View Sequence)P08176  (View Sequence)
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Der p 1.0104Peptidase 1U11695.1  (View Sequence)-P08176  (View Sequence)
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Der p 1.0105Peptidase 1U11695.1  (View Sequence)-P08176  (View Sequence)
1XKG 2AS8 1xkg  2as8  
Der p 1.0106Peptidase 1U11695.1  (View Sequence)-P08176  (View Sequence)
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Der p 1.0107Peptidase 1U11695.1  (View Sequence)-P08176  (View Sequence)
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Der p 1.0108Peptidase 1U11695.1  (View Sequence)-P08176  (View Sequence)
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Der p 1.0109Peptidase 1U11695.1  (View Sequence)-P08176  (View Sequence)
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Der p 1.0110Peptidase 1U11695.1  (View Sequence)-P08176  (View Sequence)
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Der p 1.0111Peptidase 1U11695.1  (View Sequence)-P08176  (View Sequence)
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Der p 1.0112Peptidase 1U11695.1  (View Sequence)-P08176  (View Sequence)
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Der p 1.0113Der p 1 allergenDQ185508.1  (View Sequence)ABA39435.1  (View Sequence)Q3HWZ5  (View Sequence)
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Der p 1.0114Der p 1 allergenDQ185508.1  (View Sequence)-Q3HWZ5  (View Sequence)
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Der p 1.0115Der p 1 allergenDQ185508.1  (View Sequence)-Q3HWZ5  (View Sequence)
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Der p 1.0116Der p 1 allergenDQ185508.1  (View Sequence)-Q3HWZ5  (View Sequence)
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Der p 1.0117Der p 1 allergenDQ185508.1  (View Sequence)-Q3HWZ5  (View Sequence)
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Der p 1.0118Der p 1 allergenDQ185508.1  (View Sequence)-Q3HWZ5  (View Sequence)
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Der p 1.0119Der p 1 allergenDQ185508.1  (View Sequence)-Q3HWZ5  (View Sequence)
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Der p 1.0120Der p 1 allergenDQ185508.1  (View Sequence)-Q3HWZ5  (View Sequence)
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Der p 1.0121Der p 1 allergenDQ185508.1  (View Sequence)-Q3HWZ5  (View Sequence)
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Der p 1.0122Der p 1 allergenDQ185508.1  (View Sequence)-Q3HWZ5  (View Sequence)
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Der p 1.0123Der p 1 allergenDQ185508.1  (View Sequence)-Q3HWZ5  (View Sequence)
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Der p 1.0124Der p 1 allergenFM177224.1  (View Sequence)CAQ68250.1  (View Sequence)C7T6L6  (View Sequence)
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Sequence Analysis

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Cross-links to Allergen Databases

IUISIUIS-Allergen
Allergome310
AllFamAF030

IgE Epitope Data

Allergen Isoallergen / Isoform Epitope Type of Epitope Sequence Position View on Structure IEDB Antibody Used IMGT AgAbDb Link Nature of Epitope Assay Reference Comment
Der p 1Der p 1.0101E111;D113;115RQ116;R118;253GR254;278AQ279;Y283;D296;Y299;Y301Discontinuous/ Conformational111;113;115-116;118;253-254;278-279;283;296;299;3013RVW  3RVX  4PP1  
4PP2  
174340Monoclonal antibody 4C1IMGT/3Dstructure-DBAgAbDb-Allergen-Antibody Complex Structure22210776Unique cross-reactive epitope
Der p 1Der p 1.0101110AE111;D113;115RQ116;R118;253GRT255;276SNAQG280;282DY283;I285;296DN297;Y301Discontinuous/ Conformational110-111;113;115-116;118;253-255;276-280;282-283;285;296-297;3013RVW  3RVX  4PP1  
4PP2  
422892Monoclonal antibody 10B9IMGT/3Dstructure-DBAgAbDb-Allergen-Antibody Complex Structure26026055-
Der p 1Der p 1.0101Y145;R149;151QSL153;181IQHNG185;Q188;Y191;205NAQRFGIS212;319IL320Discontinuous/ Conformational145;149;151-153;181-185;188;191;205-212;319-3203RVW  3RVX  4PP1  
4PP2  
422893Monoclonal antibody 5H8IMGT/3Dstructure-DBAgAbDb-Allergen-Antibody Complex Structure26026055-

IgE Antibody Data

Antibody data Allergen data
Antibody/ Chain Description Clone/ Isolate Antibody Source IMGT NCBI Protein (GenPept) Broad Allergen Category Allergen Id /Name Material used for Sensitization Allergic Disease Antibody studied in Reference
IgE Heavy chain variable region 5Patient 2Homo sapiensAJ002771-RespiratoryDer p 1House dust mite, Cat, GrassAtopic asthmaAdult9808205
IgE Heavy chain variable region 5Patient 3Homo sapiensAJ002776-RespiratoryDer p 1House dust mite, Cat, GrassAtopic asthmaAdult9808205

Cross-reactivity Data

Allergen Cross-reactive Allergens Reference
Der p 1Blo t 1  (View AllerBase Entry)
Der f 1  (View AllerBase Entry)
12642844
Der p 1Der f 1   (View AllerBase Entry)2428855,3611539
Der p 1Blo t 1   (View AllerBase Entry)27997997