Database of 2187 Experimentally Validated Allergens

Conformational (Discontinuous) IgE Epitopes

Number of Records:  29

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Allergen Isoallergen / Variant Epitope Type of Epitope Sequence Position View on Structure IEDB Antibody Used IMGT AgAbDb Link Nature of Epitope Assay Reference Comment
Api m 2Api m 2.0101R170;173HPFWDDQR180Discontinuous/ Conformational170;173-1801FCQ  1FCU  1FCV  2J88  77406Monoclonal antibody 21E11IMGT/3Dstructure-DBAgAbDb-Allergen-Antibody Complex Structure17374540-
Bet v 1Bet v 1.010143ENIEGNGGPGT53;R71,D73,H77,I87,K98Discontinuous/ Conformational43-53;71,73,77,87,981B6F  1BTV  1BV1  1FSK  1LLT  1QMR  
4A80  4A81  4A83  4A84  4A85  4A86  
4A87  4A88  4A8G  4B9R  4BK6  4BK7  
4BKC  4BKD  4BTZ  4MNS  4QIP  4Z3L  
77350Antibody BV16IMGT/3Dstructure-DBAgAbDb-Allergen-Antibody Complex Structure10861069-
Bet v 1Bet v 1.0101R71-F80;G2-F4;I45-K56Discontinuous/ Conformational71-80;2-4;45-561B6F  1BTV  1BV1  1FSK  4A80  4A81  
4A83  4A84  4A85  4A86  4A87  4A88  
4A8G  4B9R  4BK6  4BK7  4BKC  4BKD  
4BTZ  4MNS  4QIP  4Z3L  
-Monoclonal antibody 6H4---Hydrogen / Deuterium exchange-MS29171882-
Bla g 2Bla g 2.010185KPKYISDGN93;107RGIE110;122QQD124;153NALK156Discontinuous/ Conformational85-93;107-110;122-124;153-1561YG9  3LIZ  2NR6  4RLD  98668Monoclonal antibody 7C11IMGT/3Dstructure-DBAgAbDbEpitope on Bla g 2 homodimerAllergen-Antibody Complex Structure18519566-
Bla g 2Bla g 2.0101224IGDT227;249KAYVNPINEAI259;275DCSKIPSLPDVT286;295NISSQ299Discontinuous/ Conformational224-227;249-259;275-286;295-2991YG9  3LIZ  2NR6  4RLD  143264Monoclonal antibody 4C3IMGT/3Dstructure-DBAgAbDb-Allergen-Antibody Complex Structure, ELISA21789239-
Bla g 2Bla g 2.0101K156;F187;K278Discontinuous/ Conformational156;187;2781YG9  3LIZ  2NR6  4RLD  ----Site-directed mutagenesis, Structural analysis, ELISA26644466-
Blo t 21Blo t 21.0101E90;D95;E100;E105;D112;K123Discontinuous/ Conformational90;95;100;105;112;1232LM9  175541IgE from serum of B. tropicalis allergic patients---ELISA and NMR structure22887997-
Blo t 5Blo t 5.0101E93;D98;E103;E108Discontinuous/ Conformational93;98;103;1082JMH  2JRK  2MEY  97784IgE from serum of patients allergic to B.tropicalis extract---NMR Structure and Antigen Competition18684949-
Bos d 5Bos d 5.010134TWY36;59VEE61;K63;E71;L73;Q75;81ECAQKK86;141TPE143;169PT170;172LEEQ175;177HI178Discontinuous/ Conformational34-36;59-60;61;63;71;73;75;81-86;141-143;169-170;172-175;177-1781B0O  1B8E  1BEB  1BSO  1BSQ  1BSY  
1CJ5  1DV9  1GXA  1QG5  1UZ2  1YUP  
2AKQ  2BLG  2GJ5  2Q2M  2Q2P  2Q39  
2R56  3BLG  3KZA  3NPO  3PH5  3PH6  
3UEU  3UEV  3UEW  3UEX  4DQ3  4DQ4  
4GNY  4IB7  4IB8  4IB9  4IBA  4KII  
4LZU  4LZV  4Y0P  4Y0Q  4Y0R  
151535IgE Fab Fragment from milk-allergic patientIMGT/3Dstructure-DBAgAbDb-Allergen-Antibody Complex Structure17997967-
Der f 1Der f 1.0106E112;D114;116RS117;R119;254GR255;279TQ280;Y284;D297;Y300;Y302Discontinuous/ Conformational112;114;116-117;119;254-255;279-280;284;297;300;3023RVV  3D6S  174338Monoclonal antibody 4C1IMGT/3Dstructure-DBAgAbDb-Allergen-Antibody Complex Structure22210776Unique cross-reactive epitope
Der f 21Der f 21.0101K27;K43;K59-E60;K63;K65Discontinuous/ Conformational27;43;59-60;63;655YNX  5YNY  886587IgE from serum from patients atopic to D. farinae extract, rDer f 21---Site-directed mutagenesis with dot-blot assay30894561-
Der p 1Der p 1.0101E111;D113;115RQ116;R118;253GR254;278AQ279;Y283;D296;Y299;Y301Discontinuous/ Conformational111;113;115-116;118;253-254;278-279;283;296;299;3013RVW  3RVX  4PP1  4PP2  174340Monoclonal antibody 4C1IMGT/3Dstructure-DBAgAbDb-Allergen-Antibody Complex Structure22210776Unique cross-reactive epitope
Der p 1Der p 1.0101110AE111;D113;115RQ116;R118;253GRT255;276SNAQG280;282DY283;I285;296DN297;Y301Discontinuous/ Conformational110-111;113;115-116;118;253-255;276-280;282-283;285;296-297;3013RVW  3RVX  4PP1  4PP2  422892Monoclonal antibody 10B9IMGT/3Dstructure-DBAgAbDb-Allergen-Antibody Complex Structure26026055-
Der p 1Der p 1.0101Y145;R149;151QSL153;181IQHNG185;Q188;Y191;205NAQRFGIS212;319IL320Discontinuous/ Conformational145;149;151-153;181-185;188;191;205-212;319-3203RVW  3RVX  4PP1  4PP2  422893Monoclonal antibody 5H8IMGT/3Dstructure-DBAgAbDb-Allergen-Antibody Complex Structure26026055-
Der p 2Der p 2.010330HR31;K33;S57;93NV94;96KI97;100KSE102Discontinuous/ Conformational30-31;33;57;93-94;96-97;100-1026OY4  77738Monoclonal antibody (mAb) 7A1---NMR, Mutagenesis and ELISA11134039-
Der p 2Der p 2.0103M111;V116Discontinuous/ Conformational111;1166OY4  77739Monoclonal antibody (mAb) 6D6---NMR, Mutagenesis and ELISA11134039-
Der p 2Der p 2.010372AC73;Y75Discontinuous/ Conformational72-73;756OY4  77737Monoclonal antibody (mAb) AlphaDpX---NMR, Mutagenesis and ELISA11134039-
Der p 2Der p 2.010331RGKP34;96KI97Discontinuous/ Conformational31-34;96-976OY4  -Murine IgG mAb 7A1---X-ray crystallography31554696The epitope overlaps with human IgE epitope
Der p 7Der p 7.0101S173;175LDP177Discontinuous/ Conformational173;175-1773H4Z  188007Mouse monoclonal antibody (MoAb) WH9 that inhibits IgE-binding---Site-directed mutagenesis with Western / Immunoblot23940735L175, D176 critical for inhibition of IgE-binding to Der p 7
Fel d 1Fel d 1.0101L34;T37;39TP40;E42;E45;R61;64KN65;D68;E73;K76Discontinuous/ Conformational34;37;39-40;42;45;61;64-65;68;73;761PUO  1ZKR  2EJN  -Monoclonal antibody MAbC48---Structure model, ELISA26797272Epitope on Chain A
Gal d 4Gal d 4.010132RHG34;37NYR39;80WW81;90SRNL93;N95;T107;N111;114KKI116;118SDG120Discontinuous/ Conformational32-34;37-39;80-81;90-93;95;107;111;114-116;118-1201NDG  193L  1AKI  1AT5  1BGI  1IOR  
1JA2  1JIS  1KIP  2BLX  3WUL  3ZEK  
4A8A  4BAD  5DLA  5LYM  5LYZ  9LYZ  
146698Anti-Lysozyme Antibody HyHEL-8IMGT/3Dstructure-DBAgAbDb-Allergen-Antibody Complex Structure, SPR12740607-
Hev b 6Hev b 6.02R22;K27;46EY47;H52;Q55Discontinuous/ Conformational22;27;46-47;52;551Q9B  1T0W  4WP4  1WKX  1HEV  77722IgE from serum of patients allergic to Natural rubber latex---Antigen Competition and Structural modeling14764736-
Oct f TPI-A72;G75;S70;D76;T74;F73;V68Discontinuous/ Conformational72;75;70;76;74;73;68--IgE from sera of mollusk-allergic patients ---Phage Display28208072-
Per a 4-D32;D65;E96;Q121Discontinuous/ Conformational32;65;96;1213EBW  102993IgE from serum of patients allergic to Per a 4---Site-directed mutagenesis with dot-blot assay and ELISA19056737-
Phl p 2Phl p 2.0101E56;E58;R60;H62;65DEW67;A69;N91;93RFL95;99GMKNVFDD106;P120Discontinuous/ Conformational56;58;60;62;65-67;69;91;93-95;99-106;1201BMW  1WHO  2VXQ  1WHP  151551IgE from serum of grass pollen allergic patientsIMGT/3Dstructure-DBAgAbDb-Allergen-Antibody Complex Structure, SPR, Competition ELISA19201867-
Pru av 1Pru av 1.0101N29Discontinuous/ Conformational291E09  1H2O  77553IgE from serum of cherry-allergic patients---EAST, SPR15330760Cross-reactive IgE epitope
Scy p 8Scy p 8.0101L131;E135;P166;W168;A169;I170;T172;K174;T175;Q180Discontinuous/ Conformational131;135;166;168;169;170;172;174;175;1806JOX  910122Serum from Crab-allergic patients---ELISA30187588-
Scy s Trp-D2-K6;Q9-A10Discontinuous/ Conformational2-6;9-10--IgE from serum of crab-allergic patients---ELISA / Blot30107732-
Scy s Trp-R160-K161;D163-V172;A174;L176Discontinuous/ Conformational160-161;163-172;174;176--IgE from serum of crab-allergic patients---ELISA / Blot30107732-