| Allergen |
Isoallergen / Variant |
Epitope |
Type of Epitope |
Sequence Position |
View on Structure |
IEDB |
Antibody Used |
IMGT |
AgAbDb Link |
Nature of Epitope |
Assay |
Reference |
Comment |
| Api m 2 | Api m 2.0101 | R170;173HPFWDDQR180 | Discontinuous/ Conformational | 170;173-180 | 1FCQ 1FCU 1FCV 2J88 | 77406 | Monoclonal antibody 21E11 | IMGT/3Dstructure-DB | AgAbDb | - | Allergen-Antibody Complex Structure | 17374540 | - |
| Bet v 1 | Bet v 1.0101 | 43ENIEGNGGPGT53;R71,D73,H77,I87,K98 | Discontinuous/ Conformational | 43-53;71,73,77,87,98 | 1B6F 1BTV 1BV1 1FSK 1LLT 1QMR
4A80 4A81 4A83 4A84 4A85 4A86
4A87 4A88 4A8G 4B9R 4BK6 4BK7
4BKC 4BKD 4BTZ 4MNS 4QIP 4Z3L
| 77350 | Antibody BV16 | IMGT/3Dstructure-DB | AgAbDb | - | Allergen-Antibody Complex Structure | 10861069 | - |
| Bet v 1 | Bet v 1.0101 | R71-F80;G2-F4;I45-K56 | Discontinuous/ Conformational | 71-80;2-4;45-56 | 1B6F 1BTV 1BV1 1FSK 4A80 4A81
4A83 4A84 4A85 4A86 4A87 4A88
4A8G 4B9R 4BK6 4BK7 4BKC 4BKD
4BTZ 4MNS 4QIP 4Z3L | - | Monoclonal antibody 6H4 | - | - | - | Hydrogen / Deuterium exchange-MS | 29171882 | - |
| Bla g 2 | Bla g 2.0101 | 85KPKYISDGN93;107RGIE110;122QQD124;153NALK156 | Discontinuous/ Conformational | 85-93;107-110;122-124;153-156 | 1YG9 3LIZ 2NR6 4RLD | 98668 | Monoclonal antibody 7C11 | IMGT/3Dstructure-DB | AgAbDb | Epitope on Bla g 2 homodimer | Allergen-Antibody Complex Structure | 18519566 | - |
| Bla g 2 | Bla g 2.0101 | 224IGDT227;249KAYVNPINEAI259;275DCSKIPSLPDVT286;295NISSQ299 | Discontinuous/ Conformational | 224-227;249-259;275-286;295-299 | 1YG9 3LIZ 2NR6 4RLD | 143264 | Monoclonal antibody 4C3 | IMGT/3Dstructure-DB | AgAbDb | - | Allergen-Antibody Complex Structure, ELISA | 21789239 | - |
| Bla g 2 | Bla g 2.0101 | K156;F187;K278 | Discontinuous/ Conformational | 156;187;278 | 1YG9 3LIZ 2NR6 4RLD | - | | - | - | - | Site-directed mutagenesis, Structural analysis, ELISA | 26644466 | - |
| Blo t 21 | Blo t 21.0101 | E90;D95;E100;E105;D112;K123 | Discontinuous/ Conformational | 90;95;100;105;112;123 | 2LM9 | 175541 | IgE from serum of B. tropicalis allergic patients | - | - | - | ELISA and NMR structure | 22887997 | - |
| Blo t 5 | Blo t 5.0101 | E93;D98;E103;E108 | Discontinuous/ Conformational | 93;98;103;108 | 2JMH 2JRK 2MEY | 97784 | IgE from serum of patients allergic to B.tropicalis extract | - | - | - | NMR Structure and Antigen Competition | 18684949 | - |
| Bos d 5 | Bos d 5.0101 | 34TWY36;59VEE61;K63;E71;L73;Q75;81ECAQKK86;141TPE143;169PT170;172LEEQ175;177HI178 | Discontinuous/ Conformational | 34-36;59-60;61;63;71;73;75;81-86;141-143;169-170;172-175;177-178 | 1B0O 1B8E 1BEB 1BSO 1BSQ 1BSY
1CJ5 1DV9 1GXA 1QG5 1UZ2 1YUP
2AKQ 2BLG 2GJ5 2Q2M 2Q2P 2Q39
2R56 3BLG 3KZA 3NPO 3PH5 3PH6
3UEU 3UEV 3UEW 3UEX 4DQ3 4DQ4
4GNY 4IB7 4IB8 4IB9 4IBA 4KII
4LZU 4LZV 4Y0P 4Y0Q 4Y0R | 151535 | IgE Fab Fragment from milk-allergic patient | IMGT/3Dstructure-DB | AgAbDb | - | Allergen-Antibody Complex Structure | 17997967 | - |
| Can f 1 | Can f 1.0101 | H86 | Discontinuous/ Conformational | 86 | 7DRU | 1642896 | Sera from dog-allergic patients | - | - | - | Mutagenesis, ELISA | 34699686 | - |
| Can f 1 | Can f 1.0101 | R152 | Discontinuous/ Conformational | 152 | 7DRU | 1642897 | Sera from dog-allergic patients | - | - | - | Mutagenesis, ELISA | 34699686 | - |
| Cra a 2 | Cra a 2.0101 | S2,D3,L4,P5,L7,W8,K9,K10,S13,S16,K21,K33,A44,D45,L52,L54,D190 | Discontinuous/ Conformational | | - | - | IgE from sera of Oyster-allergic patients | - | - | - | Dot blot,iELISA | 36205062 | - |
| Cra a 2 | Cra a 2.0101 | R48,N53,P130,P131,N183,M187,G192,N195,W197,N216,C264,H308 | Discontinuous/ Conformational | | - | - | IgE from sera of Oyster-allergic patients | - | - | - | Dot blot,iELISA | 36205062 | - |
| Cra a 2 | Cra a 2.0101 | D107,I113,V114,S115,R117,D177,M226,Q227,R302,I304,S311,V312,V315 | Discontinuous/ Conformational | | - | - | IgE from sera of Oyster-allergic patients | - | - | - | Dot blot,iELISA | 36205062 | - |
| Cra a 2 | Cra a 2.0101 | D107,F112,I113,V114,S115,D177,H178,G229,H277,I304,H305,G306,S311,V312,G313,G314,V315 | Discontinuous/ Conformational | | - | - | IgE from sera of Oyster-allergic patients | - | - | - | Dot blot,iELISA | 36205062 | - |
| Der f 1 | Der f 1.0106 | E112;D114;116RS117;R119;254GR255;279TQ280;Y284;D297;Y300;Y302 | Discontinuous/ Conformational | 112;114;116-117;119;254-255;279-280;284;297;300;302 | 3RVV 3D6S | 174338 | Monoclonal antibody 4C1 | IMGT/3Dstructure-DB | AgAbDb | - | Allergen-Antibody Complex Structure | 22210776 | Unique cross-reactive epitope |
| Der f 21 | Der f 21.0101 | K27;K43;K59-E60;K63;K65 | Discontinuous/ Conformational | 27;43;59-60;63;65 | 5YNX 5YNY | 886587 | IgE from serum from patients atopic to D. farinae extract, rDer f 21 | - | - | - | Site-directed mutagenesis with dot-blot assay | 30894561 | - |
| Der p 1 | Der p 1.0101 | E111;D113;115RQ116;R118;253GR254;278AQ279;Y283;D296;Y299;Y301 | Discontinuous/ Conformational | 111;113;115-116;118;253-254;278-279;283;296;299;301 | 3RVW 3RVX 4PP1 4PP2 | 174340 | Monoclonal antibody 4C1 | IMGT/3Dstructure-DB | AgAbDb | - | Allergen-Antibody Complex Structure | 22210776 | Unique cross-reactive epitope |
| Der p 1 | Der p 1.0101 | 110AE111;D113;115RQ116;R118;253GRT255;276SNAQG280;282DY283;I285;296DN297;Y301 | Discontinuous/ Conformational | 110-111;113;115-116;118;253-255;276-280;282-283;285;296-297;301 | 3RVW 3RVX 4PP1 4PP2 | 422892 | Monoclonal antibody 10B9 | IMGT/3Dstructure-DB | AgAbDb | - | Allergen-Antibody Complex Structure | 26026055 | - |
| Der p 1 | Der p 1.0101 | Y145;R149;151QSL153;181IQHNG185;Q188;Y191;205NAQRFGIS212;319IL320 | Discontinuous/ Conformational | 145;149;151-153;181-185;188;191;205-212;319-320 | 3RVW 3RVX 4PP1 4PP2 | 422893 | Monoclonal antibody 5H8 | IMGT/3Dstructure-DB | AgAbDb | - | Allergen-Antibody Complex Structure | 26026055 | - |
| Der p 2 | Der p 2.0103 | 30HR31;K33;S57;93NV94;96KI97;100KSE102 | Discontinuous/ Conformational | 30-31;33;57;93-94;96-97;100-102 | 6OY4 7MLH | 77738 | Monoclonal antibody (mAb) 7A1 | - | - | - | NMR, Mutagenesis and ELISA | 11134039 | - |
| Der p 2 | Der p 2.0103 | M111;V116 | Discontinuous/ Conformational | 111;116 | 6OY4 7MLH | 77739 | Monoclonal antibody (mAb) 6D6 | - | - | - | NMR, Mutagenesis and ELISA | 11134039 | - |
| Der p 2 | Der p 2.0103 | 72AC73;Y75 | Discontinuous/ Conformational | 72-73;75 | 6OY4 7MLH | 77737 | Monoclonal antibody (mAb) AlphaDpX | - | - | - | NMR, Mutagenesis and ELISA | 11134039 | - |
| Der p 2 | Der p 2.0103 | 31RGKP34;96KI97 | Discontinuous/ Conformational | 31-34;96-97 | 6OY4 7MLH | - | Murine IgG mAb 7A1 | - | - | - | X-ray crystallography | 31554696 | The epitope overlaps with human IgE epitope |
| Der p 2 | Der p 2.0103 | R31;58IDGLEVD64;I97;99PKSEN103 | Discontinuous/ Conformational | 31;58-64;97;99-103 | 6OY4 7MLH | 2116021 | Human IgE mAb 2F10 | IMGT/3Dstructure-DB | AgAbDb | - | X-ray crystallography | 35799831 | - |
| Der p 23 | Der p 23.0101 | K44 | Discontinuous/ Conformational | 44 | 4ZCE | - | IgE from Der p 23 positive patients | - | - | - | Dot blot, Mutagenesis | 33441720 | Major IgE-binding residue |
| Der p 23 | Der p 23.0101 | E46 | Discontinuous/ Conformational | 46 | 4ZCE | - | IgE from Der p 23 positive patients | - | - | - | Dot blot, Mutagenesis | 33441720 | Major IgE-binding residue |
| Der p 7 | Der p 7.0101 | S173;175LDP177 | Discontinuous/ Conformational | 173;175-177 | 3H4Z | 188007 | Mouse monoclonal antibody (MoAb) WH9 that inhibits IgE-binding | - | - | - | Site-directed mutagenesis with Western / Immunoblot | 23940735 | L175, D176 critical for inhibition of IgE-binding to Der p 7 |
| Fag t 2 | Fag t 2.0101 | K132 | Discontinuous/ Conformational | 132 | - | - | Serum from buckwheat allergic patient | - | - | - | ELISA, Mutagenesis | 33412487 | IgE-binding residue |
| Fel d 1 | Fel d 1.0101 | L34;T37;39TP40;E42;E45;R61;64KN65;D68;E73;K76 | Discontinuous/ Conformational | 34;37;39-40;42;45;61;64-65;68;73;76 | 1PUO 1ZKR 2EJN | - | Monoclonal antibody MAbC48 | - | - | - | Structure model, ELISA | 26797272 | Epitope on Chain A |
| Gal d 4 | Gal d 4.0101 | 32RHG34;37NYR39;80WW81;90SRNL93;N95;T107;N111;114KKI116;118SDG120 | Discontinuous/ Conformational | 32-34;37-39;80-81;90-93;95;107;111;114-116;118-120 | 1NDG 193L 1AKI 1AT5 1BGI 1IOR
1JA2 1JIS 1KIP 2BLX 3WUL 3ZEK
4A8A 4BAD 5DLA 5LYM 5LYZ 9LYZ
| 146698 | Anti-Lysozyme Antibody HyHEL-8 | IMGT/3Dstructure-DB | AgAbDb | - | Allergen-Antibody Complex Structure, SPR | 12740607 | - |
| Hev b 6 | Hev b 6.02 | R22;K27;46EY47;H52;Q55 | Discontinuous/ Conformational | 22;27;46-47;52;55 | 1Q9B 1T0W 4WP4 1WKX 1HEV | 77722 | IgE from serum of patients allergic to Natural rubber latex | - | - | - | Antigen Competition and Structural modeling | 14764736 | - |
| Hev b 8 | Hev b 8.0102 | M1,Y6,D9,H10,C13,E14,I15,N98,R121,L122,D124,Y125,I127,D128,Q129,G130 | Discontinuous/ Conformational | | 5FDS 7SBD 7SBG | 2130785 | Murine IgE mAb 2F5 | IMGT/3Dstructure-DB | AgAbDb | - | X-ray crystallography,Western / Immunoblot | 35902770 | - |
| Oct f TPI | - | A72;G75;S70;D76;T74;F73;V68 | Discontinuous/ Conformational | 72;75;70;76;74;73;68 | - | - | IgE from sera of mollusk-allergic patients | - | - | - | Phage Display | 28208072 | - |
| Per a 4 | Per a 4.0101 | D32;D65;E96;Q121 | Discontinuous/ Conformational | 32;65;96;121 | 3EBW | 102993 | IgE from serum of patients allergic to Per a 4 | - | - | - | Site-directed mutagenesis with dot-blot assay and ELISA | 19056737 | - |
| Phl p 2 | Phl p 2.0101 | E56;E58;R60;H62;65DEW67;A69;N91;93RFL95;99GMKNVFDD106;P120 | Discontinuous/ Conformational | 56;58;60;62;65-67;69;91;93-95;99-106;120 | 1BMW 1WHO 2VXQ 1WHP | 151551 | IgE from serum of grass pollen allergic patients | IMGT/3Dstructure-DB | AgAbDb | - | Allergen-Antibody Complex Structure, SPR, Competition ELISA | 19201867 | - |
| Pru av 1 | Pru av 1.0101 | N29 | Discontinuous/ Conformational | 29 | 1E09 1H2O | 77553 | IgE from serum of cherry-allergic patients | - | - | - | EAST, SPR | 15330760 | Cross-reactive IgE epitope |
| Scy p 1 | Scy p 1.0101 | R21, E103, E104, E115, A116, E122, E156 | Discontinuous/ Conformational | | - | - | IgE from crab allergic patients | - | - | - | Dot blot | 33528481 | Residues involved in maintenance of IgE-binding |
| Scy p 1 | Scy p 1.0101 | I4,A10,M11,K12,L13,E14,D16,M19 | Discontinuous/ Conformational | | - | 2144643 | IgE from crab allergic patients | - | - | - | ELISA | 36110087 | UniProtKB:A0A6C0N3G5 |
| Scy p 1 | Scy p 1.0101 | L148,R152,L154,A158,R160,E164,V165,A166,L169,M171,V172,L176 | Discontinuous/ Conformational | | - | 2144644 | IgE from crab allergic patients | - | - | - | ELISA | 36110087 | UniProtKB:A0A6C0N3G5 |
| Scy p 1 | Scy p 1.0101 | L249,E252,V253,L256,L260,V261,N262,K264,Y267,I270,L274 | Discontinuous/ Conformational | | - | 2144645 | IgE from crab allergic patients | - | - | - | ELISA | 36110087 | UniProtKB:A0A6C0N3G5 |
| Scy p 3 | Scy p 3.0101 | L42,P44,I49,V65,D66,P70,I71,A73,V75 | Discontinuous/ Conformational | | - | 2144637 | IgE from crab allergic patients | - | - | - | ELISA | 36110087 | - |
| Scy p 3 | Scy p 3.0101 | N41,P44,T45,A47,Q74,K76,K77,K79,A81,S83,F87 | Discontinuous/ Conformational | | - | 2144640 | IgE from crab allergic patients | - | - | - | ELISA | 36110087 | - |
| Scy p 3 | Scy p 3.0101 | F87,M88,K92,L93,N99,L103,I110,L111,L114,F139 | Discontinuous/ Conformational | | - | 2144635 | IgE from crab allergic patients | - | - | - | ELISA | 36110087 | - |
| Scy p 3 | Scy p 3.0101 | V90,L93,Y94,L103,Y104,A105,E106,I110,D137,G138,F139 | Discontinuous/ Conformational | | - | 2144641 | IgE from crab allergic patients | - | - | - | ELISA | 36110087 | - |
| Scy p 3 | Scy p 3.0101 | M88,T97,G100,T101,Y104,G138,P141,P144 | Discontinuous/ Conformational | | - | 2144639 | IgE from crab allergic patients | - | - | - | ELISA | 36110087 | - |
| Scy p 3 | Scy p 3.0101 | I19,Y20,F31,C36,L40,L42,N43,L46,I49 | Discontinuous/ Conformational | | - | 2144636 | IgE from crab allergic patients | - | - | - | ELISA | 36110087 | - |
| Scy p 3 | Scy p 3.0101 | L42,P44,L46,V48,E50,K51,V52,K55,K61,L63,P70,V75,K76 | Discontinuous/ Conformational | | - | 2144638 | IgE from crab allergic patients | - | - | - | ELISA | 36110087 | - |
| Scy p 8 | Scy p 8.0101 | L131;E135;P166;W168;A169;I170;T172;K174;T175;Q180 | Discontinuous/ Conformational | 131;135;166;168;169;170;172;174;175;180 | 6JOX | 910122 | Serum from Crab-allergic patients | - | - | - | ELISA | 30187588 | - |
| Scy s Trp | - | D2-K6;Q9-A10 | Discontinuous/ Conformational | 2-6;9-10 | - | - | IgE from serum of crab-allergic patients | - | - | - | ELISA / Blot | 30107732 | - |
| Scy s Trp | - | R160-K161;D163-V172;A174;L176 | Discontinuous/ Conformational | 160-161;163-172;174;176 | - | - | IgE from serum of crab-allergic patients | - | - | - | ELISA / Blot | 30107732 | - |
