Database of 2256 Experimentally Validated Allergens

Data for Cuc m 2
WHO/IUIS recognized Allergen

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Completeness Index: Denotes availibility of data for the allergen in Binary format
1: data available
0: data not available
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AllerBase IDAB_P_00592Allergen NameCuc m 2
Source OrganismCucumis melo (Muskmelon)KingdomPlant
Biological Function/RoleActin-binding proteinMode of ExposureIngestion

Assays/Methods used for Experimental Characterization (Read More)

  :  Data Available    : Data not Available

Biological assay / test IgE assay / test Physicochemical test Cell-based assay
Basophil/Mast cell/Histamine Test  (Reference/s)EAST Chromatography  (Reference/s)Lymphocyte proliferation assay  (Reference/s)
Bronchial Test ELISA  (Reference/s)Isoelectrofocusing 
Conjunctival Test Crossed immunoelectrophoresis Mass spectrometry (MS)  (Reference/s)
Nasal Test Fluorescence Immunoassay N-terminal sequencing/sequence analysis  (Reference/s)
Oral Test Immunochemiluminescent assay 
Passive Cutaneous Anaphylaxis (PCA) ImmunoCAP Test 
Skin Test  (Reference/s)Microarray  (Reference/s)
Radio Immunoassay 
RAST 
Western/Immunoblot  (Reference/s)

Isoallergen/Variant for Cuc m 2:Available

Isoallergen/Variant Common Name GenBank Nucleotide NCBI Protein (GenPept) UniProtKB RCSB-PDB (Click on the PDB id to view structure) ETR (Evolutionary Trace analysis Report)
Cuc m 2.0101Profilin
AY879597.1  (View Sequence)AAW69549.1  (View Sequence)Q5FX67  (View Sequence)
6MBX 6mbx  

Sequence Analysis

  • BLAST
  • Pairwise alignment
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  • BLAST Nucleotide/Protein sequence of Allergen Cuc m 2 with Nucleotide or Protein sequences in AllerBase:
    Select GenBank or UniprotKB accession number by clicking on the checkbox in the above table  

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  • Align Nucleotode/Protein sequence of Your choice with Nucleotode or Protein sequence of Allergen Cuc m 2:  (Alignment job will be redirected to EMBL-EMBOSS Water or Needle tool)

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Cross-links to Allergen Databases

IUISIUIS-Allergen
Allergome981
AllFamAF051

IgE Epitope Data

Allergen Isoallergen / Isoform Epitope Type of Epitope Sequence Position View on Structure IEDB Antibody Used IMGT AgAbDb Link Nature of Epitope Assay Reference Comment
Cuc m 2Cuc m 2.0101FLGGTKYMVISequential / Linear66-75-16615IgE from serum of melon allergic patients--Major epitopeWestern / Immunoblot17397911-
Cuc m 2Cuc m 2.0101AVIRGKKGSGSequential / Linear81-90-5385IgE from serum of melon allergic patients--Major epitopeWestern / Immunoblot17397911-
Cuc m 2Cuc m 2.0101GITVKKTNQASequential / Linear91-100-20468IgE from serum of melon allergic patients--Major epitopeWestern / Immunoblot17397911-
Cuc m 2Cuc m 2.0101LGDYLIEQGLSequential / Linear122-131-36083IgE from serum of melon allergic patients--Major epitopeWestern / Immunoblot17397911-
Cuc m 2Cuc m 2.0101YVDDHLMCDIDGNRLSequential / Linear8-20-
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IgE from serum of melon allergic patients--Minor epitopeWestern / Immunoblot17397911-
Cuc m 2Cuc m 2.0101SATFPAFRLEEIAAILKDFDSequential / Linear36-55-
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IgE from serum of melon allergic patients--Minor epitopeWestern / Immunoblot17397911-
Cuc m 2Cuc m 2.0101YDEPLTPGQCNMIVESequential / Linear106-120-
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IgE from serum of melon allergic patients--Minor epitopeWestern / Immunoblot17397911-

IgE Antibody Data


No IgE Antibody Data Available

Cross-reactivity Data

Allergen Cross-reactive Allergens Reference
Cuc m 2Sin a 4   (View AllerBase Entry)20085601
Cuc m 2Bet v 2  (View AllerBase Entry)
Phl p 12  (View AllerBase Entry)
20205701
Cuc m 2Sal k 4  (View AllerBase Entry)
Ama r 2  (View AllerBase Entry)
Che a 2  (View AllerBase Entry)
Cro s 2  (View AllerBase Entry)
20622444
Cuc m 2Ama r 2  (View AllerBase Entry)
Che a 2  (View AllerBase Entry)
21430432