| Select | PubMed ID | Description |
| 2428875 | J Immunol. 1986 Nov 1;137(9):2841-7.
Antigen Der f I from the dust mite Dermatophagoides farinae: structural
comparison with Der p I from Dermatophagoides pteronyssinus and epitope
specificity of murine IgG and human IgE antibodies.
Heymann PW, Chapman MD, Platts-Mills TA.
The physicochemical and antigenic properties of an allergen purified from
Dermatophagoides farinae, Der f I, were compared with Der p I from
Dermatophagoides pteronyssinus. On SDS-PAGE, Der f I migrated as a single
polypeptide chain with the same m.w. as Der p I (24,000). Two isoallergenic peaks
of Der f I were identified on preparative isoelectric focusing (pI 5.7 to 6.3 and
pI 6.6 to 6.95). Fractions from each peak were shown to have an identical amino
acid composition (which was similar but not identical to Der p I) and the same
N-terminal amino acid sequence. There was a good correlation between quantitative
intradermal skin tests to both purified allergens and to D. farinae extract in
mite-allergic patients, with positive results when using as little as 10(-5)
micrograms/ml of Der f I. The majority of sera with detectable IgE antibody to D.
farinae also had IgE antibody to Der f I both among children (29/42 = 69%) and
adults (55/63 = 87%). By RAST, there was an excellent correlation between IgE
antibody to Der f I and Der p I in sera from 42 mite-allergic children (n = 0.94,
p less than 0.001). Polyclonal IgG antibodies from six mice immunized with Der f
I showed preferential binding to that allergen, and most monoclonal antibodies
(16 of 18) raised against Der f I did not bind Der p I. However, two monoclonal
antibodies from this fusion showed cross-reactive binding to both allergens.
Immunoabsorption experiments, using D. pteronyssinus and D. farinae extracts
coupled to Sepharose, showed that a large proportion of murine antibodies (74% to
Der p I and 60 to 93% to Der f I) could not be absorbed by the heterologous
extract on the immunosorbent. In contrast, in sera from seven mite-allergic
patients, most of the specific IgE and IgG antibody (i.e., greater than or equal
to 82%) was removed by either immunosorbent. Thus, Der f I and Der p I represent
a homologous pair of major allergens which possess both cross-reacting and
species-specific epitopes. The antibody response in mice immunized with either
allergen in complete Freund's adjuvant was largely directed against
species-specific epitopes, whereas in allergic humans, IgE- and IgG-specific
antibodies bound predominately to cross-reacting epitopes.
PMID: 2428875 [Indexed for MEDLINE]
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| 12444321 |
Int Arch Allergy Immunol. 2002 Nov;129(3):237-41.
Association between mite allergen (Der p 1, Der f 1, Blo t 5) levels and
microscopic identification of mites or skin prick test results in asthmatic
subjects.
Medeiros M Jr(1), Figueiredo JP, Almeida MC, Atta AM, Taketomi EA, Silva DA,
Terra SA, Amorim WW, Pinho RS, Araujo MI, Carvalho EM.
|
| 12744621 | Asian Pac J Allergy Immunol. 2002 Dec;20(4):217-21.
Sensitization to Dermatophagoides pteronyssinus and Blomia tropicalis extracts
and recombinant mite allergens in atopic Thai patients.
Trakultivakorn M(1), Nuglor T.
|
| 12269942 | Allergy. 2002 Oct;57(10):940-2.
Prick tests to aeroallergens: is it possible simply to wipe the device between
tests?
Piette V(1), Bourret E, Bousquet J, Demoly P.
|
| 12444321 | Int Arch Allergy Immunol. 2002 Nov;129(3):237-41.
Association between mite allergen (Der p 1, Der f 1, Blo t 5) levels and
microscopic identification of mites or skin prick test results in asthmatic
subjects.
Medeiros M Jr(1), Figueiredo JP, Almeida MC, Atta AM, Taketomi EA, Silva DA,
Terra SA, Amorim WW, Pinho RS, Araujo MI, Carvalho EM.
|
| 12464046 | Allergy. 2002 Dec;57(12):1171-9.
Farm residence and exposures and the risk of allergic diseases in New Zealand
children.
Wickens K(1), Lane JM, Fitzharris P, Siebers R, Riley G, Douwes J, Smith T, Crane
J.
|
| 12728474 | Yonsei Med J. 2003 Apr 30;44(2):313-22.
Effect of bedding control on amount of house dust mite allergens, asthma
symptoms, and peak expiratory flow rate.
Lee IS(1).
|
| 12744621 | Asian Pac J Allergy Immunol. 2002 Dec;20(4):217-21.
Sensitization to Dermatophagoides pteronyssinus and Blomia tropicalis extracts
and recombinant mite allergens in atopic Thai patients.
Trakultivakorn M(1), Nuglor T.
|
| 14707468 | Int Arch Allergy Immunol. 2003 Dec;132(4):364-72.
Allergen skin test reaction patterns in children (
families suggest age-dependent changes in allergen-IgE binding in early life.
Jackola DR(1), Pierson-Mullany L, Blumenthal MN, Rosenberg A.
|
| 14976393 | Int Arch Allergy Immunol. 2004 Mar;133(3):248-54. Epub 2004 Feb 16.
The prevalence of allergic sensitisation in immigrant children in The
Netherlands.
van Amsterdam JG(1), Bischoff EW, Hady M, Opperhuizen A, Steerenberg PA.
|
| 15005744 | Clin Exp Allergy. 2004 Mar;34(3):478-87.
Increased airway responsiveness, allergy-type-I skin responses and systemic
anaphylaxis in a humanized-severe combined immuno-deficiency mouse model.
Herz U(1), Botchkarev VA, Paus R, Renz H.
|
| 15241351 | J Allergy Clin Immunol. 2004 Jul;114(1):105-10.
Family history, dust mite exposure in early childhood, and risk for pediatric
atopy and asthma.
Cole Johnson C(1), Ownby DR, Havstad SL, Peterson EL.
|
| 16446545 | Int Arch Allergy Immunol. 2006;139(3):217-24. Epub 2006 Jan 27.
CD14 promoter polymorphisms in atopic families: implications for modulated
allergen-specific immunoglobulin E and G1 responses.
Jackola DR(1), Basu S, Liebeler CL, Willaert R, Luah SS, Oetting W, King RA,
Blumenthal MN.
|
| 16617595 | Coll Antropol. 2006 Mar;30(1):181-3.
Atopy patch test with Dermatophagoides pteronyssinus (Dp 1) in atopic dermatitis
patients.
Kuljanac I(1), Milavec-Puretić V.
|
| 16689183 | J Investig Allergol Clin Immunol. 2006;16(2):104-9.
Differential IgE reactivity to Der p 1 and Der p 2 allergens of Dermatophagoides
pteronyssinus in mite-sensitized patients.
Taketomi EA(1), Silva DA, Sopelete MC, Gervásio AM, Alves R, Sung SJ.
|
| 16689187 | J Investig Allergol Clin Immunol. 2006;16(2):129-35.
Age, gender and reactivity to allergens independently influence skin reactivity
to histamine.
Bordignon V(1), Burastero SE.
|
| 17575100 | Am J Respir Crit Care Med. 2007 Sep 1;176(5):446-53. Epub 2007 Jun 15.
Early-life allergen exposure and atopy, asthma, and wheeze up to 6 years of age.
Torrent M(1), Sunyer J, Garcia R, Harris J, Iturriaga MV, Puig C, Vall O, Anto
JM, Newman Taylor AJ, Cullinan P.
|
| 17767803 | Curr Med Res Opin. 2007 Oct;23(10):2423-31.
A double blind, placebo-controlled cross over trial of cellulose powder by nasal
provocation with Der p1 and Der f1.
Emberlin JC(1), Lewis RA.
|
| 19400901 | Clin Exp Allergy. 2009 Jul;39(7):1088-98. doi: 10.1111/j.1365-2222.2009.03264.x.
Epub 2009 Apr 21.
Engineering of major house dust mite allergens Der p 1 and Der p 2 for
allergen-specific immunotherapy.
Asturias JA(1), Ibarrola I, Arilla MC, Vidal C, Ferrer A, Gamboa PM, Viñuela JE,
Sanz ML, Andreu C, Martínez A.
|
| 20635798 | J Investig Allergol Clin Immunol. 2010;20(3):270-2.
Pattern of sensitization to major allergens Der p 1 and Der p 2 in
mite-sensitized individuals from Galicia, Spain.
Iraola V(1), Boquete M, Pinto H, Carballada F, Carballás C, Carnés J.
|
| 22321665 | Allergol Immunopathol (Madr). 2013 Jan-Feb;41(1):4-10. doi:
1016/j.aller.2011.12.005. Epub 2012 Feb 8.
Changes in IL-10 and specific antibodies associated to successful
Dermatophagoides pteronyssinus immunotherapy in children during the first year of
treatment.
Martín-Muñoz MF(1), Pineda F(2), Muiños T(3), Fontan M(3), Nevot S(4), Bosque
M(5), Jurado Palomo J(6), Torredemer A(4), Valdesoiro L(5), Martinez Cañavate
AM(7), Pedemonte Marco C(7); SEICAP Immunotherapy Work Group.
|
| 24299565 | Pediatr Allergy Immunol. 2013 Dec;24(8):752-61. doi: 10.1111/pai.12163. Epub 2013
Dec 2.
Modulation of mucosal/systemic antibody response after sublingual immunotherapy
in mite-allergic children.
Queirós MG(1), Silva DA, Siman IL, Ynoue LH, Araújo NS, Pereira FL, Almeida KC,
Miranda JS, Pena JD, Cunha-Junior JP, Taketomi EA.
|
| 25661658 | Ann Allergy Asthma Immunol. 2015 Apr;114(4):327-34. doi:
1016/j.anai.2014.12.015. Epub 2015 Feb 3.
Clinical and cytokine responses to house dust mite sublingual immunotherapy.
Potter PC(1), Baker S(2), Fenemore B(2), Nurse B(3).
|
| 28456804 | Int Arch Allergy Immunol. 2017;172(4):236-241. doi: 10.1159/000471511. Epub 2017
Apr 29.
Climate and Allergic Sensitization to Airborne Allergens in the General
Population: Data from the French Six Cities Study.
Charpin D(1), Ramadour M, Lavaud F, Raherison C, Caillaud D, de Blay F, Pauli G,
Annesi-Maesano I.
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