References/Publications for Western/Immunoblot of Cor a 1

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1715032 Mol Immunol. 1991 Aug;28(8):897-906.

The immunological relationship of epitopes on major tree pollen allergens.

Rohac M(1), Birkner T, Reimitzer I, Bohle B, Steiner R, Breitenbach M, Kraft D,
Scheiner O, Gabl F, Rumpold H.

1281178 J Allergy Clin Immunol. 1992 Dec;90(6 Pt 1):927-36.

Identification of common allergenic structures in hazel pollen and hazelnuts: a
possible explanation for sensitivity to hazelnuts in patients allergic to tree

Hirschwehr R(1), Valenta R, Ebner C, Ferreira F, Sperr WR, Valent P, Rohac M,
Rumpold H, Scheiner O, Kraft D.

7545879 Allergy. 1995 Mar;50(3):215-20.

Multiplicity of cross-reactive epitopes on Bet v I as detected with monoclonal
antibodies and human IgE.

Akkerdaas JH(1), van Ree R, Aalbers M, Stapel SO, Aalberse RC.

7916686 Eur J Biochem. 1993 Mar 1;212(2):355-62.

Four recombinant isoforms of Cor a I, the major allergen of hazel pollen, show
different IgE-binding properties.

Breiteneder H(1), Ferreira F, Hoffmann-Sommergruber K, Ebner C, Breitenbach M,
Rumpold H, Kraft D, Scheiner O.

8688676 Int Arch Allergy Immunol. 1996 Jul;110(3):282-7.

High-level expression of tree pollen isoallergens in Escherichia coli.

Weiss C(1), Kramer B, Ebner C, Susani M, Briza P, Hoffmann-Sommergruber K,
Breiteneder H, Kraft D, Scheiner O, Breitenbach M, Ferreira F.

9095245 Adv Exp Med Biol. 1996;409:219-24.

Isolation and cloning of Bet v 1-homologous food allergens from celeriac (Api g1)
and apple (Mal d1).

Hoffmann-Sommergruber K(1), Vanek-Krebitz M, Ferris R, O'Riordain G, Susani M,
Hirschwehr R, Ebner C, Ahorn H, Kraft D, Scheiner O, Breiteneder H.

11750653 Mol Immunol. 2002 Jan;38(7):515-25.

Comparison of four variants of a major allergen in hazelnut (Corylus avellana)
Cor a 1.04 with the major hazel pollen allergen Cor a 1.01.

Lüttkopf D(1), Müller U, Skov PS, Ballmer-Weber BK, Wüthrich B, Skamstrup Hansen
K, Poulsen LK, Kästner M, Haustein D, Vieths S.

12622744 Allergy. 2003 Feb;58(2):132-8.

Roasted hazelnuts--allergenic activity evaluated by double-blind,
placebo-controlled food challenge.

Hansen KS(1), Ballmer-Weber BK, Lüttkopf D, Skov PS, Wüthrich B, Bindslev-Jensen
C, Vieths S, Poulsen LK.

14600425 Int Arch Allergy Immunol. 2003 Oct;132(2):132-40.

How accurate and safe is the diagnosis of hazelnut allergy by means of commercial
skin prick test reagents?

Akkerdaas JH(1), Wensing M, Knulst AC, Krebitz M, Breiteneder H, de Vries S,
Penninks AH, Aalberse RC, Hefle SL, van Ree R.

An allergen associated with severe symptoms, Cor a 8 (lipid transfer
protein), was not detected on immunoblot in three products, and concentrations
varied by more than a factor 100 as was shown by RAST inhibition. Similar
observations were made for profilin, thaumatin-like protein and a not fully
characterized 38-kD allergen. Ratios of individual allergens were variable among
the nine extracts. SPT showed significant difference, and 6/30 patients displayed
false-negative results using 3/9 products.
CONCLUSION: Variability in the composition of products for the diagnosis of
hazelnut allergy is extreme. Sometimes, allergens implicated in severe
anaphylaxis are not detected by immunoblotting. These shortcomings in
standardisation and quality control can potentially cause a false-negative
diagnosis in subjects at risk of severe reactions to hazelnuts.

Copyright 2003 S. Karger AG, Basel

DOI: 73714
PMID: 14600425 [Indexed for MEDLINE]
Biochem J. 2004 Oct 15;383(Pt 2):327-34.

Hazelnut (Corylus avellana) vicilin Cor a 11: molecular characterization of a
glycoprotein and its allergenic activity.

Lauer I(1), Foetisch K, Kolarich D, Ballmer-Weber BK, Conti A, Altmann F, Vieths
S, Scheurer S.

16337467 J Allergy Clin Immunol. 2005 Dec;116(6):1327-33. Epub 2005 Nov 2.

Gastrointestinal digestion of Bet v 1-homologous food allergens destroys their
mediator-releasing, but not T cell-activating, capacity.

Schimek EM(1), Zwölfer B, Briza P, Jahn-Schmid B, Vogel L, Vieths S, Ebner C,
Bohle B.

18036652 J Allergy Clin Immunol. 2008 Feb;121(2):423-428.e2. Epub 2007 Nov 26.

Lipid transfer protein-linked hazelnut allergy in children from a
non-Mediterranean birch-endemic area.

Flinterman AE(1), Akkerdaas JH, den Hartog Jager CF, Rigby NM, Fernandez-Rivas M,
Hoekstra MO, Bruijnzeel-Koomen CA, Knulst AC, van Ree R, Pasmans SG.

18686294 Mol Nutr Food Res. 2008 Nov;52 Suppl 2:S262-71. doi: 10.1002/mnfr.200700426.

Expression and characterization of three important panallergens from hazelnut.

Lauer I(1), Alessandri S, Pokoj S, Reuter A, Conti A, Vieths S, Scheurer S.

24053565 Allergy. 2013 Nov;68(11):1377-86. doi: 10.1111/all.12236. Epub 2013 Sep 21.

Kinetics, cross-reactivity, and specificity of Bet v 1-specific IgG4 antibodies
induced by immunotherapy with birch pollen.

Subbarayal B(1), Schiller D, Möbs C, de Jong NW, Ebner C, Reider N, Bartel D,
Lidholm J, Pfützner W, Gerth van Wijk R, Vieths S, Bohle B.