| 14600425 | Int Arch Allergy Immunol. 2003 Oct;132(2):132-40.
How accurate and safe is the diagnosis of hazelnut allergy by means of commercial
skin prick test reagents?
Akkerdaas JH(1), Wensing M, Knulst AC, Krebitz M, Breiteneder H, de Vries S,
Penninks AH, Aalberse RC, Hefle SL, van Ree R.
An allergen associated with severe symptoms, Cor a 8 (lipid transfer
protein), was not detected on immunoblot in three products, and concentrations
varied by more than a factor 100 as was shown by RAST inhibition. Similar
observations were made for profilin, thaumatin-like protein and a not fully
characterized 38-kD allergen. Ratios of individual allergens were variable among
the nine extracts. SPT showed significant difference, and 6/30 patients displayed
false-negative results using 3/9 products.
CONCLUSION: Variability in the composition of products for the diagnosis of
hazelnut allergy is extreme. Sometimes, allergens implicated in severe
anaphylaxis are not detected by immunoblotting. These shortcomings in
standardisation and quality control can potentially cause a false-negative
diagnosis in subjects at risk of severe reactions to hazelnuts.
Copyright 2003 S. Karger AG, Basel
DOI: 73714
PMID: 14600425 [Indexed for MEDLINE]
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| 18036652 |
J Allergy Clin Immunol. 2008 Feb;121(2):423-428.e2. Epub 2007 Nov 26.
Lipid transfer protein-linked hazelnut allergy in children from a
non-Mediterranean birch-endemic area.
Flinterman AE(1), Akkerdaas JH, den Hartog Jager CF, Rigby NM, Fernandez-Rivas M,
Hoekstra MO, Bruijnzeel-Koomen CA, Knulst AC, van Ree R, Pasmans SG.
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