Database of 2281 Experimentally Validated Allergens

Data for Fel d 1
WHO/IUIS recognized Allergen

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Completeness Index: Denotes availibility of data for the allergen in Binary format
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0: data not available
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AllerBase IDAB_A_00799Allergen NameFel d 1
Source OrganismFelis domesticus (Domestic cat)KingdomAnimal
Biological Function/RoleUteroglobinMode of ExposureInhalation

Assays/Methods used for Experimental Characterization (Read More)

  :  Data Available    : Data not Available

Biological assay / test IgE assay / test Physicochemical test Cell-based assay
Basophil/Mast cell/Histamine Test  (Reference/s)EAST  (Reference/s)Chromatography  (Reference/s)Lymphocyte proliferation assay  (Reference/s)
Bronchial Test  (Reference/s)ELISA  (Reference/s)Isoelectrofocusing 
Conjunctival Test  (Reference/s)Crossed immunoelectrophoresis  (Reference/s)Mass spectrometry (MS)  (Reference/s)
Nasal Test Fluorescence Immunoassay  (Reference/s)N-terminal sequencing/sequence analysis  (Reference/s)
Oral Test Immunochemiluminescent assay 
Passive Cutaneous Anaphylaxis (PCA)  (Reference/s)ImmunoCAP Test  (Reference/s)
Skin Test  (Reference/s)Microarray  (Reference/s)
Radio Immunoassay  (Reference/s)
RAST  (Reference/s)
Western/Immunoblot  (Reference/s)

Isoallergen/Variant for Fel d 1:Available

Isoallergen/Variant Common Name GenBank Nucleotide NCBI Protein (GenPept) UniProtKB RCSB-PDB (Click on the PDB id to view structure) ETR (Evolutionary Trace analysis Report)
Fel d 1.0101Major allergen I chain 1
M74952.1  (View Sequence)AAC37318.1  (View Sequence)P30438  (View Sequence)
1PUO 1ZKR 2EJN 
5VYF 
1puo  1zkr  2ejn  
5vyf  
Fel d 1.0101Major allergen I chain 2M77341.1  (View Sequence)AAC41616.1  (View Sequence)P30440  (View Sequence)
1PUO 1ZKR 2EJN 
5VYF 
1puo  1zkr  2ejn  
5vyf  

Sequence Analysis

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Cross-links to Allergen Databases

IUISIUIS-Allergen
Allergome345
AllFamAF134

IgE Epitope Data

Allergen Isoallergen / Isoform Epitope Type of Epitope Sequence Position View on Structure IEDB Antibody Used IMGT AgAbDb Link Nature of Epitope Assay Reference Comment
Fel d 1Fel d 1.0101L34;T37;39TP40;E42;E45;R61;64KN65;D68;E73;K76Discontinuous/ Conformational34;37;39-40;42;45;61;64-65;68;73;761PUO  1ZKR  2EJN  
-Monoclonal antibody MAbC48---Structure model, ELISA26797272Epitope on Chain A
Fel d 1Fel d 1.0101VAQYKALPVVLENASequential / Linear47-601PUO  1ZKR  2EJN  
67729IgE from serum of Cat allergic patients---Radio Immunoassay7508463Epitope on Chain A
Fel d 1Fel d 1.0101DAKMTEEDKENALSSequential / Linear68-811PUO  1ZKR  2EJN  
7562IgE from serum of Cat allergic patients---Radio Immunoassay7508463Epitope on Chain A
Fel d 1Fel d 1.0101FAVANGNELLLDLSSequential / Linear32-451PUO  1ZKR  2EJN  
15295IgE from serum of Cat allergic patients---Radio Immunoassay7508463Epitope on Chain B
Fel d 1Fel d 1.0101EICPAVKRDVDLFLTGSequential / Linear23-381PUO  1ZKR  2EJN  
12408Monoclonal antibody---Radio Immunoassay7687098Epitope on Chain A
Fel d 1Fel d 1.0101LDKIYTSPLCSequential / Linear82-921PUO  1ZKR  2EJN  
37165Monoclonal antibody---Radio Immunoassay7687098Epitope on Chain A
Fel d 1Fel d 1.0101VKMAETCPIFYDVFSequential / Linear18-311ZKR  2EJN  69271Monoclonal antibody---Radio Immunoassay7687098Epitope on Chain B
Fel d 1Fel d 1.0101KKIQDCYVENGLISequential / Linear60-721PUO  1ZKR  2EJN  
31580Monoclonal antibody---Radio Immunoassay7687098Epitope on Chain A

IgE Antibody Data

Antibody data Allergen data
Antibody/ Chain Description Clone/ Isolate Antibody Source IMGT NCBI Protein (GenPept) Broad Allergen Category Allergen Id /Name Material used for Sensitization Allergic Disease Antibody studied in Reference
Monoclonal antibody MAbC48-Mus musculus--RespiratoryFel d 1Cat hair extract, recombinant Fel d 1Not specifiedNot specified26797272
Fab light chainPDB:5VYF--RespiratoryFel d 1CatNot specifiedNot specified-
Fab heavy chainPDB:5VYF--RespiratoryFel d 1CatNot specifiedNot specified-

Cross-reactivity Data

Allergen Cross-reactive Allergens Reference
Fel d 1Can f CRA   (View AllerBase Entry)17210049
Fel d 1Can f 1   (View AllerBase Entry)34224230