Database of 2233 Experimentally Validated Allergens

Data for Der p 7
WHO/IUIS recognized Allergen

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AllerBase IDAB_A_00726Allergen NameDer p 7
Source OrganismDermatophagoides pteronyssinus (European house dust mite)KingdomAnimal
Biological Function/RoleUnknownMode of ExposureInhalation

Assays/Methods used for Experimental Characterization (Read More)

  :  Data Available    : Data not Available

Biological assay / test IgE assay / test Physicochemical test Cell-based assay
Basophil/Mast cell/Histamine Test  (Reference/s)EAST Chromatography Lymphocyte proliferation assay  (Reference/s)
Bronchial Test ELISA  (Reference/s)Isoelectrofocusing 
Conjunctival Test Crossed immunoelectrophoresis Mass spectrometry (MS)  (Reference/s)
Nasal Test Fluorescence Immunoassay N-terminal sequencing/sequence analysis 
Oral Test Immunochemiluminescent assay 
Passive Cutaneous Anaphylaxis (PCA) ImmunoCAP Test  (Reference/s)
Skin Test  (Reference/s)Microarray  (Reference/s)
Radio Immunoassay  (Reference/s)
RAST  (Reference/s)
Western/Immunoblot  (Reference/s)

Isoallergen/Variant for Der p 7:Available

Isoallergen/Variant Common Name GenBank Nucleotide NCBI Protein (GenPept) UniProtKB RCSB-PDB (Click on the PDB id to view structure) ETR (Evolutionary Trace analysis Report)
Der p 7.0101Mite allergen Der p 7
U37044.1  (View Sequence)AAA80264.1  (View Sequence)P49273  (View Sequence)
3H4Z 3h4z  

Sequence Analysis

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Cross-links to Allergen Databases

IUISIUIS-Allergen
Allergome321
AllFamAF195

IgE Epitope Data

Allergen Isoallergen / Isoform Epitope Type of Epitope Sequence Position View on Structure IEDB Antibody Used IMGT AgAbDb Link Nature of Epitope Assay Reference Comment
Der p 7Der p 7.0101S173;175LDP177Discontinuous/ Conformational173;175-1773H4Z  188007Mouse monoclonal antibody (MoAb) WH9 that inhibits IgE-binding---Site-directed mutagenesis with Western / Immunoblot23940735L175, D176 critical for inhibition of IgE-binding to Der p 7
Der p 7Der p 7.0101DPIHYDKITEEINKAVDEAVAAIEKSETFDSequential / Linear18-473H4Z  969047IgE from serum of house dust mite allergic patients---Dot blot, antigen inhibition34220841-

IgE Antibody Data

Antibody data Allergen data
Antibody/ Chain Description Clone/ Isolate Antibody Source IMGT NCBI Protein (GenPept) Broad Allergen Category Allergen Id /Name Material used for Sensitization Allergic Disease Antibody studied in Reference
Monoclonal antibody WH9 heavy chain-Mus musculusKC222648AGT38394.1RespiratoryDer p 7House dust miteNot specifiedNot specified23940735
Monoclonal antibody WH9 light chain-Mus musculusKC222649AGT38395.1RespiratoryDer p 7House dust miteNot specifiedNot specified23940735

Cross-reactivity Data

Allergen Cross-reactive Allergens Reference
Der p 7Blo t 7   (View AllerBase Entry)29356186
Der p 7Der f 7   (View AllerBase Entry)9249276