Database of 2297 Experimentally Validated Allergens

Data for Der p 2
WHO/IUIS recognized Allergen

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AllerBase IDAB_A_00716Allergen NameDer p 2
Source OrganismDermatophagoides pteronyssinus (European house dust mite)KingdomAnimal
Biological Function/RoleNPC2 family proteinMode of ExposureInhalation

Assays/Methods used for Experimental Characterization (Read More)

  :  Data Available    : Data not Available

Biological assay / test IgE assay / test Physicochemical test Cell-based assay
Basophil/Mast cell/Histamine Test  (Reference/s)EAST Chromatography  (Reference/s)Lymphocyte proliferation assay  (Reference/s)
Bronchial Test  (Reference/s)ELISA  (Reference/s)Isoelectrofocusing 
Conjunctival Test Crossed immunoelectrophoresis  (Reference/s)Mass spectrometry (MS)  (Reference/s)
Nasal Test Fluorescence Immunoassay  (Reference/s)N-terminal sequencing/sequence analysis  (Reference/s)
Oral Test Immunochemiluminescent assay  (Reference/s)
Passive Cutaneous Anaphylaxis (PCA) ImmunoCAP Test  (Reference/s)
Skin Test  (Reference/s)Microarray  (Reference/s)
Radio Immunoassay  (Reference/s)
RAST  (Reference/s)
Western/Immunoblot  (Reference/s)

Isoallergen/Variant for Der p 2:Available

Isoallergen/Variant Common Name GenBank Nucleotide NCBI Protein (GenPept) UniProtKB RCSB-PDB (Click on the PDB id to view structure) ETR (Evolutionary Trace analysis Report)
Der p 2.0101Mite group 2 allergen Der p 2
AF276239.1  (View Sequence)AAF86462.1  (View Sequence)P49278  (View Sequence)
1A9V 1KTJ 1a9v  1ktj  
Der p 2.0102Mite group 2 allergen Der p 2--P49278  (View Sequence)
--
Der p 2.0103Mite group 2 allergen Der p 2--P49278,I2CMD6  (View Sequence)
6OY4 7MLH 6oy4  7mlh  
Der p 2.0104Mite group 2 allergen Der p 2--P49278  (View Sequence)
--
Der p 2.0105Mite group 2 allergen Der p 2--P49278  (View Sequence)
--
Der p 2.0106Mite group 2 allergen Der p 2--P49278  (View Sequence)
--
Der p 2.0107Mite group 2 allergen Der p 2--P49278  (View Sequence)
--
Der p 2.0108Mite group 2 allergen Der p 2--P49278  (View Sequence)
--
Der p 2.0109Der p 2 allergen-----
Der p 2.0110Der p 2 allergenFM177223.1  (View Sequence)CAQ68249.1  (View Sequence)C7T6L5  (View Sequence)
--
Der p 2.0111Der p 2 allergen-----
Der p 2.0112Der p 2 allergen-----
Der p 2.0113Der p 2 allergen-----
Der p 2.0114Der p 2 allergenAM263560.1  (View Sequence)CAK22338.1  (View Sequence)Q1H8P8  (View Sequence)
--
Der p 2.0115Der p 2 allergenFM177223.1  (View Sequence)CAQ68249.1  (View Sequence)C7T6L5  (View Sequence)
--

Sequence Analysis

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Cross-links to Allergen Databases

IUISIUIS-Allergen
Allergome316
AllFamAF111

IgE Epitope Data

Allergen Isoallergen / Isoform Epitope Type of Epitope Sequence Position View on Structure IEDB Antibody Used IMGT AgAbDb Link Nature of Epitope Assay Reference Comment
Der p 2Der p 2.010330HR31;K33;S57;93NV94;96KI97;100KSE102Discontinuous/ Conformational30-31;33;57;93-94;96-97;100-1026OY4  7MLH  77738Monoclonal antibody (mAb) 7A1---NMR, Mutagenesis and ELISA11134039-
Der p 2Der p 2.0103M111;V116Discontinuous/ Conformational111;1166OY4  7MLH  77739Monoclonal antibody (mAb) 6D6---NMR, Mutagenesis and ELISA11134039-
Der p 2Der p 2.010372AC73;Y75Discontinuous/ Conformational72-73;756OY4  7MLH  77737Monoclonal antibody (mAb) AlphaDpX---NMR, Mutagenesis and ELISA11134039-
Der p 2Der p 2.0101VPGIDPNACHYMKCSequential / Linear82-951A9V  1KTJ  70304IgE from human antiserum---Radio Immuno Assay and Antigen Competition1720504Residue V1 is modified by Acetylation
Der p 2Der p 2.010331RGKP34;96KI97Discontinuous/ Conformational31-34;96-976OY4  7MLH  -Murine IgG mAb 7A1---X-ray crystallography31554696The epitope overlaps with human IgE epitope
Der p 2Der p 2.0103R31;58IDGLEVD64;I97;99PKSEN103Discontinuous/ Conformational31;58-64;97;99-1036OY4  7MLH  2116021Human IgE mAb 2F10IMGT/3Dstructure-DBAgAbDb-X-ray crystallography35799831-

IgE Antibody Data

Antibody data Allergen data
Antibody/ Chain Description Clone/ Isolate Antibody Source IMGT NCBI Protein (GenPept) Broad Allergen Category Allergen Id /Name Material used for Sensitization Allergic Disease Antibody studied in Reference
IgE mAb 2F10 light chainPDB:7MLHHomo sapiens--RespiratoryDer p 2Dust miteNot specifiedNot specified35799831
IgE mAb 2F10 heavy chainPDB:7MLHHomo sapiens--RespiratoryDer p 2Dust miteNot specifiedNot specified35799831

Cross-reactivity Data

Allergen Cross-reactive Allergens Reference
Der p 2Der f 2  (View AllerBase Entry)
Eur m 2  (View AllerBase Entry)
12372994
Der p 2Gly d 2   (View AllerBase Entry)17412407
Der p 2Tyr p 2   (View AllerBase Entry)20683648
Der p 2Blo t 2   (View AllerBase Entry)31439916