Database of 2297 Experimentally Validated Allergens

Data for Der f 21
WHO/IUIS recognized Allergen

1  1  1  0  1  1  1  0  1 
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AllerBase IDAB_A_00682Allergen NameDer f 21
Source OrganismDermatophagoides farinae (American house dust mite)KingdomAnimal
Biological Function/RoleMite group-21 allergenMode of ExposureInhalation

Assays/Methods used for Experimental Characterization (Read More)

  :  Data Available    : Data not Available

Biological assay / test IgE assay / test Physicochemical test Cell-based assay
Basophil/Mast cell/Histamine Test EAST Chromatography  (Reference/s)Lymphocyte proliferation assay 
Bronchial Test ELISA  (Reference/s)Isoelectrofocusing 
Conjunctival Test Crossed immunoelectrophoresis Mass spectrometry (MS)  (Reference/s)
Nasal Test Fluorescence Immunoassay N-terminal sequencing/sequence analysis 
Oral Test Immunochemiluminescent assay 
Passive Cutaneous Anaphylaxis (PCA) ImmunoCAP Test 
Skin Test  (Reference/s)Microarray 
Radio Immunoassay 
RAST 
Western/Immunoblot  (Reference/s)

Isoallergen/Variant for Der f 21:Available

Isoallergen/Variant Common Name GenBank Nucleotide NCBI Protein (GenPept) UniProtKB RCSB-PDB (Click on the PDB id to view structure) ETR (Evolutionary Trace analysis Report)
Der f 21.0101Allergen Der f 21
KF732965.1  (View Sequence)AHC94806.1  (View Sequence)B2GM84  (View Sequence)
5YNX 5YNY 5ynx  5yny  

Sequence Analysis

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  • BLAST Nucleotide/Protein sequence of Allergen Der f 21 with Nucleotide or Protein sequences in AllerBase:
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Cross-links to Allergen Databases

IUISIUIS-Allergen
Allergome5843
AllFamAF156

IgE Epitope Data

Allergen Isoallergen / Isoform Epitope Type of Epitope Sequence Position View on Structure IEDB Antibody Used IMGT AgAbDb Link Nature of Epitope Assay Reference Comment
Der f 21Der f 21.0101K27;K43;K59-E60;K63;K65Discontinuous/ Conformational27;43;59-60;63;655YNX  5YNY  886587IgE from serum from patients atopic to D. farinae extract, rDer f 21---Site-directed mutagenesis with dot-blot assay30894561-

IgE Antibody Data


No IgE Antibody Data Available

Cross-reactivity Data

Allergen Cross-reactive Allergens Reference
Der f 21Der f 5  (View AllerBase Entry)
Blo t 5  (View AllerBase Entry)
26238285
Der f 21Tyr p 5  (View AllerBase Entry)
Tyr p 21  (View AllerBase Entry)
Blo t 5  (View AllerBase Entry)
Blo t 21  (View AllerBase Entry)
26238285
Der f 21Der f 5   (View AllerBase Entry)27069539