Database of 2297 Experimentally Validated Allergens

Data for Bla g 2
WHO/IUIS recognized Allergen

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Completeness Index: Denotes availibility of data for the allergen in Binary format
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AllerBase IDAB_A_00305Allergen NameBla g 2
Source OrganismBlattella germanica (German cockroach)KingdomAnimal
Biological Function/RoleAspartic proteaseMode of ExposureInhalation

Assays/Methods used for Experimental Characterization (Read More)

  :  Data Available    : Data not Available

Biological assay / test IgE assay / test Physicochemical test Cell-based assay
Basophil/Mast cell/Histamine Test  (Reference/s)EAST Chromatography  (Reference/s)Lymphocyte proliferation assay  (Reference/s)
Bronchial Test ELISA  (Reference/s)Isoelectrofocusing 
Conjunctival Test Crossed immunoelectrophoresis Mass spectrometry (MS)  (Reference/s)
Nasal Test Fluorescence Immunoassay N-terminal sequencing/sequence analysis  (Reference/s)
Oral Test Immunochemiluminescent assay 
Passive Cutaneous Anaphylaxis (PCA) ImmunoCAP Test  (Reference/s)
Skin Test  (Reference/s)Microarray  (Reference/s)
Radio Immunoassay  (Reference/s)
RAST  (Reference/s)
Western/Immunoblot  (Reference/s)

Isoallergen/Variant for Bla g 2:Available

Isoallergen/Variant Common Name GenBank Nucleotide NCBI Protein (GenPept) UniProtKB RCSB-PDB (Click on the PDB id to view structure) ETR (Evolutionary Trace analysis Report)
Bla g 2.0101Aspartic protease Bla g 2
U28863.1  (View Sequence)AAA86744.1  (View Sequence)P54958  (View Sequence)
1YG9 3LIZ 2NR6 
4RLD 
1yg9  3liz  2nr6  
4rld  

Sequence Analysis

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Cross-links to Allergen Databases

IUISIUIS-Allergen
Allergome141
AllFamAF004

IgE Epitope Data

Allergen Isoallergen / Isoform Epitope Type of Epitope Sequence Position View on Structure IEDB Antibody Used IMGT AgAbDb Link Nature of Epitope Assay Reference Comment
Bla g 2Bla g 2.010185KPKYISDGN93;107RGIE110;122QQD124;153NALK156Discontinuous/ Conformational85-93;107-110;122-124;153-1561YG9  3LIZ  2NR6  
4RLD  
98668Monoclonal antibody 7C11IMGT/3Dstructure-DBAgAbDbEpitope on Bla g 2 homodimerAllergen-Antibody Complex Structure18519566-
Bla g 2Bla g 2.0101224IGDT227;249KAYVNPINEAI259;275DCSKIPSLPDVT286;295NISSQ299Discontinuous/ Conformational224-227;249-259;275-286;295-2991YG9  3LIZ  2NR6  
4RLD  
143264Monoclonal antibody 4C3IMGT/3Dstructure-DBAgAbDb-Allergen-Antibody Complex Structure, ELISA21789239-
Bla g 2Bla g 2.0101K156;F187;K278Discontinuous/ Conformational156;187;2781YG9  3LIZ  2NR6  
4RLD  
----Site-directed mutagenesis, Structural analysis, ELISA26644466-

IgE Antibody Data

Antibody data Allergen data
Antibody/ Chain Description Clone/ Isolate Antibody Source IMGT NCBI Protein (GenPept) Broad Allergen Category Allergen Id /Name Material used for Sensitization Allergic Disease Antibody studied in Reference
Fab light chainPDB:2NR6Mus musculus--RespiratoryBla g 2rBla g 2Not specifiedNot specified18519566
Fab heavy chainPDB:2NR6Mus musculus--RespiratoryBla g 2rBla g 2Not specifiedNot specified18519566
4C3 mAb light chainPDB:3LIZMus musculus--RespiratoryBla g 2rBla g 2Not specifiedNot specified21789239
4C3 mAb heavy chainPDB:3LIZMus musculus--RespiratoryBla g 2rBla g 2Not specifiedNot specified21789239

Cross-reactivity Data

Allergen Cross-reactive Allergens Reference
Bla g 2Rhi o 1   (View AllerBase Entry)26672984