Database of 2297 Experimentally Validated Allergens

Data for Api m 2
WHO/IUIS recognized Allergen

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AllerBase IDAB_A_00154Allergen NameApi m 2
Source OrganismApis mellifera (Honey bee)KingdomAnimal
Biological Function/RoleHyaluronidaseMode of ExposureSting

Assays/Methods used for Experimental Characterization (Read More)

  :  Data Available    : Data not Available

Biological assay / test IgE assay / test Physicochemical test Cell-based assay
Basophil/Mast cell/Histamine Test  (Reference/s)EAST Chromatography  (Reference/s)Lymphocyte proliferation assay  (Reference/s)
Bronchial Test ELISA  (Reference/s)Isoelectrofocusing 
Conjunctival Test Crossed immunoelectrophoresis Mass spectrometry (MS) 
Nasal Test Fluorescence Immunoassay N-terminal sequencing/sequence analysis 
Oral Test Immunochemiluminescent assay 
Passive Cutaneous Anaphylaxis (PCA) ImmunoCAP Test  (Reference/s)
Skin Test  (Reference/s)Microarray 
Radio Immunoassay 
RAST  (Reference/s)
Western/Immunoblot  (Reference/s)

Isoallergen/Variant for Api m 2:Available

Isoallergen/Variant Common Name GenBank Nucleotide NCBI Protein (GenPept) UniProtKB RCSB-PDB (Click on the PDB id to view structure) ETR (Evolutionary Trace analysis Report)
Api m 2.0101Hyaluronidase
L10710.1  (View Sequence)AAA27730.1  (View Sequence)Q08169  (View Sequence)
1FCQ 1FCU 1FCV 
2J88 
1fcq  1fcu  1fcv  
2j88  

Sequence Analysis

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  • BLAST Nucleotide/Protein sequence of Allergen Api m 2 with Nucleotide or Protein sequences in AllerBase:
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Cross-links to Allergen Databases

IUISIUIS-Allergen
Allergome46
AllFamAF103

IgE Epitope Data

Allergen Isoallergen / Isoform Epitope Type of Epitope Sequence Position View on Structure IEDB Antibody Used IMGT AgAbDb Link Nature of Epitope Assay Reference Comment
Api m 2Api m 2.0101R170;173HPFWDDQR180Discontinuous/ Conformational170;173-1801FCQ  1FCU  1FCV  
2J88  
77406Monoclonal antibody 21E11IMGT/3Dstructure-DBAgAbDb-Allergen-Antibody Complex Structure17374540-

IgE Antibody Data

Antibody data Allergen data
Antibody/ Chain Description Clone/ Isolate Antibody Source IMGT NCBI Protein (GenPept) Broad Allergen Category Allergen Id /Name Material used for Sensitization Allergic Disease Antibody studied in Reference
Fab light chainPDB:2J88Mus musculus--ContactApi m 2Recombinant HyaluronidaseNot specifiedNot specified17374540
Fab heavy chainPDB:2J88Mus musculus--ContactApi m 2Recombinant HyaluronidaseNot specifiedNot specified17374540

Cross-reactivity Data

Allergen Cross-reactive Allergens Reference
Api m 2Api d Hyal   (View AllerBase Entry)28712914
Api m 2Dol m 2   (View AllerBase Entry)7876212