AllerBase Allergen Database

Data for Scy p 1

WHO/IUIS recognized Allergen

1 1 1 0 1 0 0 0 1

Completeness Index: Denotes availibility of data for the allergen in Binary format
1: data available
0: data not available

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AllerBase ID	AB_A_01662	Allergen Name	Scy p 1
Source Organism	Scylla paramamosain (Mud crab)	Kingdom	Animal
Biological Function/Role	Muscle contraction protein	Mode of Exposure	Ingestion

Assays/Methods used for Experimental Characterization (Read More)

: Data Available

: Data not Available

Biological assay / test	IgE assay / test	Physicochemical test	Cell-based assay
Basophil/Mast cell/Histamine Test (Reference/s)	EAST	Chromatography (Reference/s)	Lymphocyte proliferation assay
Bronchial Test	ELISA (Reference/s)	Isoelectrofocusing
Conjunctival Test	Crossed immunoelectrophoresis	Mass spectrometry (MS) (Reference/s)
Nasal Test	Fluorescence Immunoassay	N-terminal sequencing/sequence analysis
Oral Test (Reference/s)	Immunochemiluminescent assay
Passive Cutaneous Anaphylaxis (PCA)	ImmunoCAP Test
Skin Test	Microarray
	Radio Immunoassay
	RAST
	Western/Immunoblot (Reference/s)

Isoallergen/Variant for Scy p 1:

Available

Isoallergen/Variant	Common Name	GenBank Nucleotide	NCBI Protein (GenPept)	UniProtKB	RCSB-PDB (Click on the PDB id to view structure)	ETR (Evolutionary Trace analysis Report)
Scy p 1.0101	Tropomyosin	EF672351.1 (View Sequence)	ABS12233.1 (View Sequence)	A7L5V2 (View Sequence)	-	-

Sequence Analysis

BLAST
Pairwise alignment
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BLAST Nucleotide/Protein sequence of Allergen Scy p 1 with Nucleotide or Protein sequences in AllerBase:
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Cross-links to Allergen Databases

IUIS	IUIS-Allergen
Allergome	9160
AllFam	-

IgE Epitope Data

Allergen	Isoallergen / Isoform	Epitope	Type of Epitope	Sequence Position	View on Structure	IEDB	Antibody Used	IMGT	AgAbDb Link	Nature of Epitope	Assay	Reference	Comment
Scy p 1	Scy p 1.0101	R21, E103, E104, E115, A116, E122, E156	Discontinuous/ Conformational		-	-	IgE from crab allergic patients	-	-	-	Dot blot	33528481	Residues involved in maintenance of IgE-binding
Scy p 1	Scy p 1.0101	AQEQLSAANTKL	Sequential / Linear	60-71	-	2144611	IgE from crab allergic patients	-	-	-	Dot blot	36110087	UniProtKB:A0A6C0N3G5
Scy p 1	Scy p 1.0101	ALQNAEGEVAALNR	Sequential / Linear	77-90	-	2144610	IgE from crab allergic patients	-	-	-	Dot blot	36110087	UniProtKB:A0A6C0N3G5
Scy p 1	Scy p 1.0101	RSEERLNTAT	Sequential / Linear	101-110	-	2144630	IgE from crab allergic patients	-	-	-	Dot blot	36110087	UniProtKB:A0A6C0N3G5
Scy p 1	Scy p 1.0101	LAEASQAADESER	Sequential / Linear	113-125	-	2144620	IgE from crab allergic patients	-	-	-	Dot blot	36110087	UniProtKB:A0A6C0N3G5
Scy p 1	Scy p 1.0101	MRKVLENRSLSDEE	Sequential / Linear	126-139	-	2144626	IgE from crab allergic patients	-	-	-	Dot blot	36110087	UniProtKB:A0A6C0N3G5
Scy p 1	Scy p 1.0101	RMDALENQLKEARFLAEEADRKY	Sequential / Linear	140-162	-	2144629	IgE from crab allergic patients	-	-	-	Dot blot	36110087	UniProtKB:A0A6C0N3G5
Scy p 1	Scy p 1.0101	DEVARKLAMVEAD	Sequential / Linear	163-175	-	2144617	IgE from crab allergic patients	-	-	-	Dot blot	36110087	UniProtKB:A0A6C0N3G5
Scy p 1	Scy p 1.0101	LERAEERAESGES	Sequential / Linear	176-188	-	2144622	IgE from crab allergic patients	-	-	-	Dot blot	36110087	UniProtKB:A0A6C0N3G5
Scy p 1	Scy p 1.0101	KIVELEEELRVVGNNLKSLEVS	Sequential / Linear	189-210	-	2144619	IgE from crab allergic patients	-	-	-	Dot blot	36110087	UniProtKB:A0A6C0N3G5
Scy p 1	Scy p 1.0101	EEKANQREETYKEQIKTLANK	Sequential / Linear	211-231	-	2144618	IgE from crab allergic patients	-	-	-	Dot blot	36110087	UniProtKB:A0A6C0N3G5
Scy p 1	Scy p 1.0101	I4,A10,M11,K12,L13,E14,D16,M19	Discontinuous/ Conformational		-	2144643	IgE from crab allergic patients	-	-	-	ELISA	36110087	UniProtKB:A0A6C0N3G5
Scy p 1	Scy p 1.0101	L148,R152,L154,A158,R160,E164,V165,A166,L169,M171,V172,L176	Discontinuous/ Conformational		-	2144644	IgE from crab allergic patients	-	-	-	ELISA	36110087	UniProtKB:A0A6C0N3G5
Scy p 1	Scy p 1.0101	L249,E252,V253,L256,L260,V261,N262,K264,Y267,I270,L274	Discontinuous/ Conformational		-	2144645	IgE from crab allergic patients	-	-	-	ELISA	36110087	UniProtKB:A0A6C0N3G5

IgE Antibody Data

No IgE Antibody Data Available

Cross-reactivity Data

Allergen	Cross-reactive Allergens	Reference
Scy p 1	Cra a Trp (View AllerBase Entry) Hal di Trp (View AllerBase Entry) Chla n Trp (View AllerBase Entry) Pat y Trp (View AllerBase Entry) Ven ph Trp (View AllerBase Entry) Sol st Trp (View AllerBase Entry) Lit v 1 (View AllerBase Entry) Cra g 1 (View AllerBase Entry)	35848932