AllerBase Allergen Database

Database of 2313 Experimentally Validated Allergens

Data for Phl p 5

WHO/IUIS recognized Allergen

1 1 1 1 1 1 0 1 1

Completeness Index: Denotes availibility of data for the allergen in Binary format
1: data available
0: data not available

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AllerBase ID	AB_P_01420	Allergen Name	Phl p 5
Source Organism	Phleum pratense (Timothy grass)	Kingdom	Plant
Biological Function/Role	Ribonuclease	Mode of Exposure	Inhalation

Assays/Methods used for Experimental Characterization (Read More)

: Data Available

: Data not Available

Biological assay / test	IgE assay / test	Physicochemical test	Cell-based assay
Basophil/Mast cell/Histamine Test (Reference/s)	EAST (Reference/s)	Chromatography (Reference/s)	Lymphocyte proliferation assay (Reference/s)
Bronchial Test (Reference/s)	ELISA (Reference/s)	Isoelectrofocusing
Conjunctival Test (Reference/s)	Crossed immunoelectrophoresis	Mass spectrometry (MS) (Reference/s)
Nasal Test (Reference/s)	Fluorescence Immunoassay	N-terminal sequencing/sequence analysis (Reference/s)
Oral Test	Immunochemiluminescent assay
Passive Cutaneous Anaphylaxis (PCA)	ImmunoCAP Test (Reference/s)
Skin Test (Reference/s)	Microarray (Reference/s)
	Radio Immunoassay
	RAST (Reference/s)
	Western/Immunoblot (Reference/s)

Isoallergen/Variant for Phl p 5:

Available

Isoallergen/Variant	Common Name	GenBank Nucleotide	NCBI Protein (GenPept)	UniProtKB	RCSB-PDB (Click on the PDB id to view structure)	ETR (Evolutionary Trace analysis Report)
Phl p 5.0101	Phlp5	X74735.1 (View Sequence)	CAA52753.1 (View Sequence)	Q40960 (View Sequence)	2M64	2m64
Phl p 5.0102	Pollen allergen Phl p 5a	X70942.1 (View Sequence)	CAA50281.1 (View Sequence)	Q40962 (View Sequence)	-	-
Phl p 5.0103	Group V allergen Phl p 5.0103	AF069470.1 (View Sequence)	AAC25994.1 (View Sequence)	O81341 (View Sequence)	-	-
Phl p 5.0104	Major allergen Phl p 5	Z82986.1 (View Sequence)	CAB05372.1 (View Sequence)	P93467 (View Sequence)	-	-
Phl p 5.0105	Major allergen Phl p 5	AF061066.1 (View Sequence)	AAC16525.1 (View Sequence)	O65318 (View Sequence)	-	-
Phl p 5.0106	Major allergen Phl p 5	AF061067.1 (View Sequence)	AAC16526.1 (View Sequence)	O65319 (View Sequence)	-	-
Phl p 5.0107	Major allergen Phl p 5	AF061068.1 (View Sequence)	AAC16527.1 (View Sequence)	O65320 (View Sequence)	-	-
Phl p 5.0108	Major allergen Phl p 5	AF061069.1 (View Sequence)	AAC16528.1 (View Sequence)	O65321 (View Sequence)	-	-
Phl p 5.0109	Phl p5a allergen	AJ555152.1 (View Sequence)	CAD87529.1 (View Sequence)	Q84UI2 (View Sequence)	-	-
Phl p 5.0201	Pollen allergen Phl p 5b	Z27083.1 (View Sequence)	CAA81609.1 (View Sequence)	Q40963 (View Sequence)	1L3P	1l3p
Phl p 5.0202	Major allergen Phl p 5	Z82985.1 (View Sequence)	CAB05371.1 (View Sequence)	P93466 (View Sequence)	-	-
Phl p 5.0203	Group V allergen Phl p 5.0203	AF069471.1 (View Sequence)	AAC25995.1 (View Sequence)	O81342 (View Sequence)	-	-
Phl p 5.0204	Group V allergen Phl p 5.0204	-	-	Q9SBE0 (View Sequence)	-	-
Phl p 5.0205	Phl p 5.0205	-	-	-	-	-
Phl p 5.0206	Group V allergen Phl p 5.0206	AF069473.1 (View Sequence)	AAC25997.1 (View Sequence)	O81343 (View Sequence)	-	-
Phl p 5.0207	Group V allergen Phl p 5.0207	AF069474.1 (View Sequence)	AAC25998.1 (View Sequence)	O81344 (View Sequence)	-	-

Sequence Analysis

BLAST
Pairwise alignment
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BLAST Nucleotide/Protein sequence of Allergen Phl p 5 with Nucleotide or Protein sequences in AllerBase:
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Cross-links to Allergen Databases

IUIS	IUIS-Allergen
Allergome	558
AllFam	AF102

IgE Epitope Data

No Epitope Data Available

IgE Antibody Data

Antibody data

Allergen data

Antibody/ Chain Description	Clone/ Isolate	Antibody Source	IMGT	NCBI Protein (GenPept)	Broad Allergen Category	Allergen Id /Name	Material used for Sensitization	Allergic Disease	Antibody studied in	Reference
IgE heavy chain variable region	A3-EE50B	Homo sapiens	DQ065702	ABA00112.1	Respiratory	Phl p 5	Timothy grass, Cat, Birch	Allergic rhinitis	Adult	17825890
IgE heavy chain variable region	A3-EE50	Homo sapiens	DQ065703	ABA00113.1	Respiratory	Phl p 5	Timothy grass, Cat, Birch	Allergic rhinitis	Adult	17825890
IgE heavy chain variable region	A3-EE44B	Homo sapiens	DQ065707	ABA00117.1	Respiratory	Phl p 5	Timothy grass, Cat, Birch	Allergic rhinitis	Adult	17825890
IgE heavy chain variable region	A3-EE38	Homo sapiens	DQ065710	ABA00120.1	Respiratory	Phl p 5	Timothy grass, Cat, Birch	Allergic rhinitis	Adult	17825890
IgE heavy chain variable region	A3-EE10	Homo sapiens	DQ065727	ABA00137.1	Respiratory	Phl p 5	Timothy grass, Cat, Birch	Allergic rhinitis	Adult	17825890
Single chain antibody fragment	p5-1	Synthetic construct	EF607111	ABS72427.1	Respiratory	Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	17825890
Single chain antibody fragment	p5-3	Synthetic construct	EF607112	ABS72428.1	Respiratory	Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	17825890
Single chain antibody fragment	p5-8	Synthetic construct	EF607113	ABS72429.1	Respiratory	Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	17825890
Single chain antibody fragment	p5-9	Synthetic construct	EF607114	ABS72430.1	Respiratory	Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	17825890
Single chain antibody fragment	p5-11	Synthetic construct	EF607115	ABS72431.1	Respiratory	Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	17825890
Single chain antibody fragment	p5-13	Synthetic construct	EF607116	ABS72432.1	Respiratory	Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	17825890
Single chain antibody fragment	p5-16	Synthetic construct	EF607117	ABS72433.1	Respiratory	Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	17825890
Single chain antibody fragment	p5-17	Synthetic construct	EF607118	ABS72434.1	Respiratory	Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	17825890
Single chain antibody fragment	p5-18	Synthetic construct	EF607119	ABS72435.1	Respiratory	Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	17825890
Single chain antibody fragment	P5-AB5	Synthetic construct	EF601887	ABV03180.1	Respiratory	Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	17825890
Single chain antibody fragment	p6-1	Synthetic construct	EF607120	ABS72436.1	Respiratory	Phl p 6, Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	17825890
Single chain antibody fragment	p6-12	Synthetic construct	EF607121	ABS72437.1	Respiratory	Phl p 6, Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	17825890
Single chain antibody fragment	p6-19	Synthetic construct	EF607122	ABS72438.1	Respiratory	Phl p 6, Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	17825890
Single chain antibody fragment	p6-21	Synthetic construct	EF607123	ABS72439.1	Respiratory	Phl p 6, Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	17825890
Single chain antibody fragment	p6-36	Synthetic construct	EF607124	ABS72440.1	Respiratory	Phl p 6, Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	17825890
Single chain antibody fragment	4.1	Synthetic construct	DQ065729	AAZ86719.1	Respiratory	Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	16905150
Single chain antibody fragment	4.2	Synthetic construct	DQ065730	AAZ86720.1	Respiratory	Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	16905150
Single chain antibody fragment	4.3	Synthetic construct	DQ065731	AAZ86721.1	Respiratory	Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	16905150
Single chain antibody fragment	4.4	Synthetic construct	DQ065732	AAZ86722.1	Respiratory	Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	16905150
Single chain antibody fragment	4.10	Synthetic construct	DQ065733	AAZ86723.1	Respiratory	Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	16905150
Single chain antibody fragment	4.12	Synthetic construct	DQ065734	AAZ86724.1	Respiratory	Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	16905150
Single chain antibody fragment	4.13	Synthetic construct	DQ065735	AAZ86725.1	Respiratory	Phl p 5	Timothy grass, Mugwort, Birch	Allergic rhinitis	Not specified	16905150
Immunoglobulin epsilon chain	5, 14, 28, 31	Homo sapiens	X95746	CAA65057.1	Respiratory	Phl p 5	Grass pollen	Allergic conjunctivitis, Allergic rhinitis	Adult	8631916
Immunoglobulin kappa chain	5	Synthetic construct	X95747	CAA65058.1	Respiratory	Phl p 5	Grass pollen	Allergic conjunctivitis, Allergic rhinitis	Adult	8631916
Immunoglobulin kappa chain	28	Synthetic construct	X95748	CAA65059.1	Respiratory	Phl p 5	Grass pollen	Allergic conjunctivitis, Allergic rhinitis	Adult	8631916
Immunoglobulin kappa chain	14	Synthetic construct	X95749	CAA65060.1	Respiratory	Phl p 5	Grass pollen	Allergic conjunctivitis, Allergic rhinitis	Adult	8631916
Immunoglobulin kappa chain	31	Synthetic construct	X95750	CAA65061.1	Respiratory	Phl p 5	Grass pollen	Allergic conjunctivitis, Allergic rhinitis	Adult	8631916

Cross-reactivity Data

Allergen	Cross-reactive Allergens	Reference
Phl p 5	Sec c 5 (View AllerBase Entry) Lol p 5 (View AllerBase Entry) Poa p 5 (View AllerBase Entry)	11034391
Phl p 5	Phl p 6 (View AllerBase Entry)	7544180
Phl p 5	Lol p 1 (View AllerBase Entry)	8634519
Phl p 5	Phl p 2 (View AllerBase Entry) Phl p 1 (View AllerBase Entry) Bet v 2 (View AllerBase Entry)	9500760