AllerBase Allergen Database

Database of 2313 Experimentally Validated Allergens

Data for Hev b 8

WHO/IUIS recognized Allergen

1 1 1 0 1 1 1 1 1

Completeness Index: Denotes availibility of data for the allergen in Binary format
1: data available
0: data not available

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AllerBase ID	AB_P_00956	Allergen Name	Hev b 8
Source Organism	Hevea brasiliensis (Para rubber tree)	Kingdom	Plant
Biological Function/Role	Actin-binding protein	Mode of Exposure	Inhalation, Contact

Assays/Methods used for Experimental Characterization (Read More)

: Data Available

: Data not Available

Biological assay / test	IgE assay / test	Physicochemical test	Cell-based assay
Basophil/Mast cell/Histamine Test (Reference/s)	EAST	Chromatography (Reference/s)	Lymphocyte proliferation assay
Bronchial Test	ELISA (Reference/s)	Isoelectrofocusing
Conjunctival Test	Crossed immunoelectrophoresis	Mass spectrometry (MS) (Reference/s)
Nasal Test	Fluorescence Immunoassay	N-terminal sequencing/sequence analysis
Oral Test	Immunochemiluminescent assay
Passive Cutaneous Anaphylaxis (PCA)	ImmunoCAP Test (Reference/s)
Skin Test	Microarray (Reference/s)
	Radio Immunoassay
	RAST
	Western/Immunoblot (Reference/s)

Isoallergen/Variant for Hev b 8:

Available

Isoallergen/Variant	Common Name	GenBank Nucleotide	NCBI Protein (GenPept)	UniProtKB	RCSB-PDB (Click on the PDB id to view structure)	ETR (Evolutionary Trace analysis Report)
Hev b 8.0101	Profilin-1	Y15042.1 (View Sequence)	CAA75312.1 (View Sequence)	O65812 (View Sequence)	-	-
Hev b 8.0102	Profilin-2	AJ132397.1 (View Sequence)	CAB51914.1 (View Sequence)	Q9STB6 (View Sequence)	5FDS 5FEG 7SBD 7SBG	5fds 5feg 7sbd 7sbg
Hev b 8.0201	Profilin-3	AF119365.1 (View Sequence)	AAF34341.1 (View Sequence)	Q9M7N0 (View Sequence)	-	-
Hev b 8.0202	Profilin-4	AF119366.1 (View Sequence)	AAF34342.1 (View Sequence)	Q9M7M9 (View Sequence)	-	-
Hev b 8.0203	Profilin-5	AF119367.1 (View Sequence)	AAF34343.1 (View Sequence)	Q9M7M8 (View Sequence)	-	-
Hev b 8.0204	Profilin-6	AJ243325.1 (View Sequence)	CAB96215.1 (View Sequence)	Q9LEI8 (View Sequence)	1G5U	1g5u

Sequence Analysis

BLAST
Pairwise alignment
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BLAST Nucleotide/Protein sequence of Allergen Hev b 8 with Nucleotide or Protein sequences in AllerBase:
Select GenBank or UniprotKB accession number by clicking on the checkbox in the above table

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Cross-links to Allergen Databases

IUIS	IUIS-Allergen
Allergome	397
AllFam	AF051

IgE Epitope Data

Allergen

Isoallergen / Isoform

Epitope

Type of Epitope

Sequence Position

View on Structure

IEDB

Antibody Used

IMGT

AgAbDb Link

Nature of Epitope

Assay

Reference

Comment

Hev b 8

Hev b 8.0102

M1,Y6,D9,H10,C13,E14,I15,N98,R121,L122,D124,Y125,I127,D128,Q129,G130

Discontinuous/ Conformational

5FDS 7SBD 7SBG

2130785

Murine IgE mAb 2F5

IMGT/3Dstructure-DB

AgAbDb

X-ray crystallography,Western / Immunoblot

35902770

IgE Antibody Data

Antibody data

Allergen data

Antibody/ Chain Description	Clone/ Isolate	Antibody Source	IMGT	NCBI Protein (GenPept)	Broad Allergen Category	Allergen Id /Name	Material used for Sensitization	Allergic Disease	Antibody studied in	Reference
Monoclonal IgE mAb 2F5	-	Mus musculus	-	-	Respiratory	Hev b 8	Recombinant allergens from Rubber tree, Maize	Not specified	Not specified	27586352
Murine IgE mAb 2F5 light chain	PDB:7SBD,7SBG	Mus musculus	-	-	Respiratory	Hev b 8	Recombinant allergen rHev b 8	Not specified	Not specified	35902770
Murine IgE mAb 2F5 heavy chain	PDB:7SBD,7SBG	Mus musculus	-	-	Respiratory	Hev b 8	Recombinant allergen rHev b 8	Not specified	Not specified	35902770

Cross-reactivity Data

Allergen	Cross-reactive Allergens	Reference
Hev b 8	Api g 4 (View AllerBase Entry)	11490154
Hev b 8	Bet v 2 (View AllerBase Entry) Mus a 1 (View AllerBase Entry) Ana c 1 (View AllerBase Entry)	12065910
Hev b 8	Che a 2 (View AllerBase Entry) Lig v 2 (View AllerBase Entry) Fra e 2 (View AllerBase Entry) Syr v PFN (View AllerBase Entry) Pla a 4 (View AllerBase Entry) Cup s PFN (View AllerBase Entry) Amb t 8 (View AllerBase Entry) Art v 4 (View AllerBase Entry) Dac g PFN (View AllerBase Entry) Par j 3 (View AllerBase Entry) Phl p 12 (View AllerBase Entry) Sola t PFN (View AllerBase Entry) Sola l 1 (View AllerBase Entry) Cap a 2 (View AllerBase Entry) Mus a 1 (View AllerBase Entry) Pru p 4 (View AllerBase Entry)	15449709
Hev b 8	Cap a 2 (View AllerBase Entry)	15544599
Hev b 8	Zea m 12 (View AllerBase Entry)	27586352
Hev b 8	Zea m 12 (View AllerBase Entry)	35902770