Database of 2313 Experimentally Validated Allergens
Data for Hev b 6
WHO/IUIS recognized Allergen

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AllerBase IDAB_P_00954Allergen NameHev b 6
Source OrganismHevea brasiliensis (Para rubber tree)KingdomPlant
Biological Function/RoleHeveinMode of ExposureInhalation, Contact

Assays/Methods used for Experimental Characterization (Read More)

  :  Data Available    : Data not Available

Biological assay / test IgE assay / test Physicochemical test Cell-based assay
Basophil/Mast cell/Histamine Test  (Reference/s)EAST  (Reference/s)Chromatography  (Reference/s)Lymphocyte proliferation assay  (Reference/s)
Bronchial Test ELISA  (Reference/s)Isoelectrofocusing 
Conjunctival Test Crossed immunoelectrophoresis Mass spectrometry (MS)  (Reference/s)
Nasal Test Fluorescence Immunoassay N-terminal sequencing/sequence analysis  (Reference/s)
Oral Test Immunochemiluminescent assay 
Passive Cutaneous Anaphylaxis (PCA) ImmunoCAP Test  (Reference/s)
Skin Test  (Reference/s)Microarray 
Radio Immunoassay 
RAST 
Western/Immunoblot  (Reference/s)

Isoallergen/Variant for Hev b 6:Available

Isoallergen/Variant Common Name GenBank Nucleotide NCBI Protein (GenPept) UniProtKB RCSB-PDB (Click on the PDB id to view structure) ETR (Evolutionary Trace analysis Report)
Hev b 6.01Pro-hevein
M36986.1  (View Sequence)AAA33357.1  (View Sequence)P02877  (View Sequence)
1T0W 1t0w  
Hev b 6.02Pro-heveinM36986.1  (View Sequence)AAA33357.1  (View Sequence)P02877  (View Sequence)
1Q9B 1WKX 1HEV 
4WP4 		1q9b  1wkx  1hev  
4wp4  
Hev b 6.03Pro-heveinM36986.1  (View Sequence)AAA33357.1  (View Sequence)P02877  (View Sequence)
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Sequence Analysis

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Cross-links to Allergen Databases

IUISIUIS-Allergen
Allergome390
AllFamAF043

IgE Epitope Data

Allergen Isoallergen / Isoform Epitope Type of Epitope Sequence Position View on Structure IEDB Antibody Used IMGT AgAbDb Link Nature of Epitope Assay Reference Comment
Hev b 6Hev b 6.02R22;K27;46EY47;H52;Q55Discontinuous/ Conformational22;27;46-47;52;551Q9B  1T0W  4WP4  
1WKX  1HEV  		77722IgE from serum of patients allergic to Natural rubber latex---Antigen Competition and Structural modeling14764736-
Hev b 6Hev b 6.01PNNLCCSQWGWCSequential / Linear30-411Q9B  1T0W  4WP4  
1WKX  1HEV  		95674IgE from serum of latex allergic subjects---Western / Immunoblot9097919-
Hev b 6Hev b 6.01EYCSPDHNSequential / Linear46-531Q9B  4WP4  1WKX  
1HEV  		95371IgE from serum of latex allergic subjects---Western / Immunoblot9097919-
Hev b 6Hev b 6.01LYNSQDHGSequential / Linear79-85-95583IgE from serum of latex allergic subjects---Western / Immunoblot9097919-
Hev b 6Hev b 6.01AASAYCSTSequential / Linear91-98-95201IgE from serum of latex allergic subjects---Western / Immunoblot9097919-
Hev b 6Hev b 6.01CSNGGLSequential / Linear151-156-95294IgE from serum of latex allergic subjects---Western / Immunoblot9097919-
Hev b 6Hev b 6.01NYQFVDCGSequential / Linear181-188-95644IgE from serum of latex allergic subjects---Western / Immunoblot9097919-

IgE Antibody Data

Antibody data Allergen data
Antibody/ Chain Description Clone/ Isolate Antibody Source IMGT NCBI Protein (GenPept) Broad Allergen Category Allergen Id /Name Material used for Sensitization Allergic Disease Antibody studied in Reference
Hev b 6.02-specific scFvA6Synthetic constructEU934735ACJ66728.1Respiratory, ContactHev b 6Hev b 6.02Not specifiedNot specified18930549
Hev b 6.02-specific scFvH8Synthetic constructEU934736ACJ66729.1Respiratory, ContactHev b 6Hev b 6.02Not specifiedNot specified18930549
Hev b 6.02-specific scFvM8Synthetic constructEU934737ACJ66730.1Respiratory, ContactHev b 6Hev b 6.02Not specifiedNot specified18930549

Cross-reactivity Data

Allergen Cross-reactive Allergens Reference
Hev b 6Fic b 45kD   (View AllerBase Entry)11146386
Hev b 6Hev b 11   (View AllerBase Entry)11940078
Hev b 6Trip s 1   (View AllerBase Entry)15876312
Hev b 6Tri a 18   (View AllerBase Entry)9097919
Hev b 6Pers a 1   (View AllerBase Entry)9774427