AllerBase Allergen Database

Database of 2313 Experimentally Validated Allergens

Data for Der p 1

WHO/IUIS recognized Allergen

1 1 1 1 1 1 1 1 1

Completeness Index: Denotes availibility of data for the allergen in Binary format
1: data available
0: data not available

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AllerBase ID	AB_A_00709	Allergen Name	Der p 1
Source Organism	Dermatophagoides pteronyssinus (European house dust mite)	Kingdom	Animal
Biological Function/Role	Cysteine protease	Mode of Exposure	Inhalation

Assays/Methods used for Experimental Characterization (Read More)

: Data Available

: Data not Available

Biological assay / test	IgE assay / test	Physicochemical test	Cell-based assay
Basophil/Mast cell/Histamine Test (Reference/s)	EAST (Reference/s)	Chromatography (Reference/s)	Lymphocyte proliferation assay (Reference/s)
Bronchial Test (Reference/s)	ELISA (Reference/s)	Isoelectrofocusing
Conjunctival Test	Crossed immunoelectrophoresis (Reference/s)	Mass spectrometry (MS) (Reference/s)
Nasal Test (Reference/s)	Fluorescence Immunoassay (Reference/s)	N-terminal sequencing/sequence analysis (Reference/s)
Oral Test	Immunochemiluminescent assay (Reference/s)
Passive Cutaneous Anaphylaxis (PCA)	ImmunoCAP Test (Reference/s)
Skin Test (Reference/s)	Microarray (Reference/s)
	Radio Immunoassay (Reference/s)
	RAST (Reference/s)
	Western/Immunoblot (Reference/s)

Isoallergen/Variant for Der p 1:

Available

Isoallergen/Variant	Common Name	GenBank Nucleotide	NCBI Protein (GenPept)	UniProtKB	RCSB-PDB (Click on the PDB id to view structure)	ETR (Evolutionary Trace analysis Report)
Der p 1.0101	Peptidase 1	U11695.1 (View Sequence)	AAB60215.1 (View Sequence)	P08176 (View Sequence)	3RVW 3RVX 3F5V 4PP1 4PP2 5VPH	3rvw 3rvx 3f5v 4pp1 4pp2 5vph
Der p 1.0102	Peptidase 1	U11695.1 (View Sequence)	AAB60215.1 (View Sequence)	P08176 (View Sequence)	-	-
Der p 1.0103	Peptidase 1	U11695.1 (View Sequence)	AAB60215.1 (View Sequence)	P08176 (View Sequence)	-	-
Der p 1.0104	Peptidase 1	U11695.1 (View Sequence)	-	P08176 (View Sequence)	-	-
Der p 1.0105	Peptidase 1	U11695.1 (View Sequence)	-	P08176 (View Sequence)	1XKG 2AS8	1xkg 2as8
Der p 1.0106	Peptidase 1	U11695.1 (View Sequence)	-	P08176 (View Sequence)	-	-
Der p 1.0107	Peptidase 1	U11695.1 (View Sequence)	-	P08176 (View Sequence)	-	-
Der p 1.0108	Peptidase 1	U11695.1 (View Sequence)	-	P08176 (View Sequence)	-	-
Der p 1.0109	Peptidase 1	U11695.1 (View Sequence)	-	P08176 (View Sequence)	-	-
Der p 1.0110	Peptidase 1	U11695.1 (View Sequence)	-	P08176 (View Sequence)	-	-
Der p 1.0111	Peptidase 1	U11695.1 (View Sequence)	-	P08176 (View Sequence)	-	-
Der p 1.0112	Peptidase 1	U11695.1 (View Sequence)	-	P08176 (View Sequence)	-	-
Der p 1.0113	Der p 1 allergen	DQ185508.1 (View Sequence)	ABA39435.1 (View Sequence)	Q3HWZ5 (View Sequence)	-	-
Der p 1.0114	Der p 1 allergen	DQ185508.1 (View Sequence)	-	Q3HWZ5 (View Sequence)	5VPG	5vpg
Der p 1.0115	Der p 1 allergen	DQ185508.1 (View Sequence)	-	Q3HWZ5 (View Sequence)	-	-
Der p 1.0116	Der p 1 allergen	DQ185508.1 (View Sequence)	-	Q3HWZ5 (View Sequence)	-	-
Der p 1.0117	Der p 1 allergen	DQ185508.1 (View Sequence)	-	Q3HWZ5 (View Sequence)	-	-
Der p 1.0118	Der p 1 allergen	DQ185508.1 (View Sequence)	-	Q3HWZ5 (View Sequence)	-	-
Der p 1.0119	Der p 1 allergen	DQ185508.1 (View Sequence)	-	Q3HWZ5 (View Sequence)	-	-
Der p 1.0120	Der p 1 allergen	DQ185508.1 (View Sequence)	-	Q3HWZ5 (View Sequence)	-	-
Der p 1.0121	Der p 1 allergen	DQ185508.1 (View Sequence)	-	Q3HWZ5 (View Sequence)	-	-
Der p 1.0122	Der p 1 allergen	DQ185508.1 (View Sequence)	-	Q3HWZ5 (View Sequence)	-	-
Der p 1.0123	Der p 1 allergen	DQ185508.1 (View Sequence)	-	Q3HWZ5 (View Sequence)	-	-
Der p 1.0124	Der p 1 allergen	FM177224.1 (View Sequence)	CAQ68250.1 (View Sequence)	C7T6L6 (View Sequence)	-	-

Sequence Analysis

BLAST
Pairwise alignment
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BLAST Nucleotide/Protein sequence of Allergen Der p 1 with Nucleotide or Protein sequences in AllerBase:
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Cross-links to Allergen Databases

IUIS	IUIS-Allergen
Allergome	310
AllFam	AF030

IgE Epitope Data

Allergen

Isoallergen / Isoform

Epitope

Type of Epitope

Sequence Position

View on Structure

IEDB

Antibody Used

IMGT

AgAbDb Link

Nature of Epitope

Assay

Reference

Comment

Der p 1

Der p 1.0101

E111;D113;115RQ116;R118;253GR254;278AQ279;Y283;D296;Y299;Y301

Discontinuous/ Conformational

111;113;115-116;118;253-254;278-279;283;296;299;301

3RVW 3RVX 4PP1
4PP2

174340

Monoclonal antibody 4C1

IMGT/3Dstructure-DB

AgAbDb

Allergen-Antibody Complex Structure

22210776

Unique cross-reactive epitope

Der p 1

Der p 1.0101

110AE111;D113;115RQ116;R118;253GRT255;276SNAQG280;282DY283;I285;296DN297;Y301

Discontinuous/ Conformational

110-111;113;115-116;118;253-255;276-280;282-283;285;296-297;301

3RVW 3RVX 4PP1
4PP2

422892

Monoclonal antibody 10B9

IMGT/3Dstructure-DB

AgAbDb

Allergen-Antibody Complex Structure

26026055

Der p 1

Der p 1.0101

Y145;R149;151QSL153;181IQHNG185;Q188;Y191;205NAQRFGIS212;319IL320

Discontinuous/ Conformational

145;149;151-153;181-185;188;191;205-212;319-320

3RVW 3RVX 4PP1
4PP2

422893

Monoclonal antibody 5H8

IMGT/3Dstructure-DB

AgAbDb

Allergen-Antibody Complex Structure

26026055

IgE Antibody Data

Antibody data

Allergen data

Antibody/ Chain Description	Clone/ Isolate	Antibody Source	IMGT	NCBI Protein (GenPept)	Broad Allergen Category	Allergen Id /Name	Material used for Sensitization	Allergic Disease	Antibody studied in	Reference
IgE Heavy chain variable region 5	Patient 2	Homo sapiens	AJ002771	-	Respiratory	Der p 1	House dust mite, Cat, Grass	Atopic asthma	Adult	9808205
IgE Heavy chain variable region 5	Patient 3	Homo sapiens	AJ002776	-	Respiratory	Der p 1	House dust mite, Cat, Grass	Atopic asthma	Adult	9808205
Fab 4C1 light chain	PDB:5VPG	Mus musculus	-	-	Respiratory	Der p 1	Der p 1	Not specified	Not specified	22210776
Fab 4C1 heavy chain	PDB:5VPG	Mus musculus	-	-	Respiratory	Der p 1	Der p 1	Not specified	Not specified	22210776

Cross-reactivity Data

Allergen	Cross-reactive Allergens	Reference
Der p 1	Blo t 1 (View AllerBase Entry) Der f 1 (View AllerBase Entry)	12642844
Der p 1	Der f 1 (View AllerBase Entry)	2428855,3611539
Der p 1	Blo t 1 (View AllerBase Entry)	27997997