Database of 2313 Experimentally Validated Allergens
Data for Der f 1
WHO/IUIS recognized Allergen

1  1  1  1  1  1  1  1  1 
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0: data not available
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AllerBase IDAB_A_00671Allergen NameDer f 1
Source OrganismDermatophagoides farinae (American house dust mite)KingdomAnimal
Biological Function/RoleCysteine proteaseMode of ExposureInhalation

Assays/Methods used for Experimental Characterization (Read More)

  :  Data Available    : Data not Available

Biological assay / test IgE assay / test Physicochemical test Cell-based assay
Basophil/Mast cell/Histamine Test  (Reference/s)EAST Chromatography  (Reference/s)Lymphocyte proliferation assay  (Reference/s)
Bronchial Test  (Reference/s)ELISA  (Reference/s)Isoelectrofocusing 
Conjunctival Test Crossed immunoelectrophoresis Mass spectrometry (MS)  (Reference/s)
Nasal Test  (Reference/s)Fluorescence Immunoassay  (Reference/s)N-terminal sequencing/sequence analysis  (Reference/s)
Oral Test Immunochemiluminescent assay  (Reference/s)
Passive Cutaneous Anaphylaxis (PCA) ImmunoCAP Test  (Reference/s)
Skin Test  (Reference/s)Microarray  (Reference/s)
Radio Immunoassay  (Reference/s)
RAST  (Reference/s)
Western/Immunoblot  (Reference/s)

Isoallergen/Variant for Der f 1:Available

Isoallergen/Variant Common Name GenBank Nucleotide NCBI Protein (GenPept) UniProtKB RCSB-PDB (Click on the PDB id to view structure) ETR (Evolutionary Trace analysis Report)
Der f 1.0101Der f 1 allergen preproenzyme
AB034946.1  (View Sequence)BAC53948.1  (View Sequence)Q58A71  (View Sequence)
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Der f 1.0102Der f 1 allergenDQ185509.1  (View Sequence)ABA39436.1  (View Sequence)Q3HWZ4  (View Sequence)
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Der f 1.0103Der f 1 allergenDQ185509.1  (View Sequence)-Q3HWZ4  (View Sequence)
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Der f 1.0104Der f 1 allergenDQ185509.1  (View Sequence)-Q3HWZ4  (View Sequence)
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Der f 1.0105Der f 1 allergenDQ185509.1  (View Sequence)-Q3HWZ4  (View Sequence)
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Der f 1.0106Peptidase 1AB034946.1  (View Sequence)BAC53948.1  (View Sequence)P16311  (View Sequence)
3RVV 3D6S 5VPL 
3rvv  3d6s  5vpl  
Der f 1.0107Der f 1 allergen-----
Der f 1.0108Der f 1 allergenEF139428.1  (View Sequence)ABL84749.1  (View Sequence)A1YW11  (View Sequence)
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Der f 1.0109Der f 1 allergenEF139429.1  (View Sequence)ABL84750.1  (View Sequence)A1YW12  (View Sequence)
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Der f 1.0110Der f 1 allergenEF139430.1  (View Sequence)ABL84751.1  (View Sequence)A1YW13  (View Sequence)
--

Sequence Analysis

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Cross-links to Allergen Databases

IUISIUIS-Allergen
Allergome295
AllFamAF030

IgE Epitope Data

Allergen Isoallergen / Isoform Epitope Type of Epitope Sequence Position View on Structure IEDB Antibody Used IMGT AgAbDb Link Nature of Epitope Assay Reference Comment
Der f 1Der f 1.0106E112;D114;116RS117;R119;254GR255;279TQ280;Y284;D297;Y300;Y302Discontinuous/ Conformational112;114;116-117;119;254-255;279-280;284;297;300;3023RVV  3D6S  174338Monoclonal antibody 4C1IMGT/3Dstructure-DBAgAbDb-Allergen-Antibody Complex Structure22210776Unique cross-reactive epitope
Der f 1-SAYLAYRNSequential / Linear144-1513RVV  3D6S  558178Pooled sera from pediatric patients with D. farinae hypersensitivity---Microarray27481284GenBank: EU095368.1
Der f 1-GCHGDTIPSequential / Linear169-1763RVV  3D6S  558069Pooled sera from pediatric patients with D. farinae hypersensitivity---Microarray27481284GenBank: EU095368.1
Der f 1-AREQQCRRPNSQSequential / Linear197-208-558007Pooled sera from pediatric patients with D. farinae hypersensitivity---Microarray27481284GenBank: EU095368.1
Der f 1-GSTQGVDYSequential / Linear277-284-558083Pooled sera from pediatric patients with D. farinae hypersensitivity---Microarray27481284GenBank: EU095368.1

IgE Antibody Data

Antibody data Allergen data
Antibody/ Chain Description Clone/ Isolate Antibody Source IMGT NCBI Protein (GenPept) Broad Allergen Category Allergen Id /Name Material used for Sensitization Allergic Disease Antibody studied in Reference
4C1 light chainPDB:5VPLMus musculus--RespiratoryDer f 1Der f 1Not specifiedNot specified22210776
4C1 heavy chainPDB:5VPLMus musculus--RespiratoryDer f 1Der f 1Not specifiedNot specified22210776

Cross-reactivity Data

Allergen Cross-reactive Allergens Reference
Der f 1Blo t 1  (View AllerBase Entry)
Der p 1  (View AllerBase Entry)
12642844
Der f 1Der p 1   (View AllerBase Entry)2428855,3611539