AllerBase Allergen Database

Data for Cra g 1

WHO/IUIS recognized Allergen

1 1 1 0 1 0 1 0 1

Completeness Index: Denotes availibility of data for the allergen in Binary format
1: data available
0: data not available

(Read More)

AllerBase ID	AB_A_00575	Allergen Name	Cra g 1
Source Organism	Crassostrea gigas (Pacific oyster)	Kingdom	Animal
Biological Function/Role	Muscle contraction protein	Mode of Exposure	Ingestion

Assays/Methods used for Experimental Characterization (Read More)

: Data Available

: Data not Available

Biological assay / test	IgE assay / test	Physicochemical test	Cell-based assay
Basophil/Mast cell/Histamine Test (Reference/s)	EAST	Chromatography (Reference/s)	Lymphocyte proliferation assay
Bronchial Test	ELISA (Reference/s)	Isoelectrofocusing
Conjunctival Test	Crossed immunoelectrophoresis	Mass spectrometry (MS) (Reference/s)
Nasal Test	Fluorescence Immunoassay (Reference/s)	N-terminal sequencing/sequence analysis
Oral Test	Immunochemiluminescent assay
Passive Cutaneous Anaphylaxis (PCA)	ImmunoCAP Test
Skin Test	Microarray
	Radio Immunoassay
	RAST
	Western/Immunoblot (Reference/s)

Isoallergen/Variant for Cra g 1:

Available

Isoallergen/Variant	Common Name	GenBank Nucleotide	NCBI Protein (GenPept)	UniProtKB	RCSB-PDB (Click on the PDB id to view structure)	ETR (Evolutionary Trace analysis Report)
Cra g 1.0101	Tropomyosin	KY549366.1 (View Sequence)	ARX70262.1 (View Sequence)	A0A1Z1VMW2 (View Sequence)	-	-
Cra g 1.0102	Tropomyosin	AB444943.1 (View Sequence)	BAH10152.1 (View Sequence)	B7XC66 (View Sequence)	-	-

Sequence Analysis

BLAST Nucleotide/Protein sequence of Allergen Cra g 1 with Nucleotide or Protein sequences in AllerBase:
Select GenBank or UniprotKB accession number by clicking on the checkbox in the above table

Default E-value cut-off for BLAST is set at 0.01.

OR
Set E-value of your choice:
Align Nucleotode/Protein sequence of Your choice with Nucleotode or Protein sequence of Allergen Cra g 1: (Alignment job will be redirected to EMBL-EMBOSS Water or Needle tool)

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*Input your Nucleotode or Protein sequence (in FASTA format) here:

Cross-links to Allergen Databases

IgE Epitope Data

Allergen	Isoallergen / Isoform	Epitope	Type of Epitope	Sequence Position	View on Structure	IEDB	Antibody Used	IMGT	AgAbDb Link	Nature of Epitope	Assay	Reference	Comment
Cra g 1	Cra g 1.0102	TSLQKK	Sequential / Linear	44-49	-	886613	IgE from pooled sera of Oyster allergic patients	-	-	Immunodominant epitope	ELISA	30807831	-
Cra g 1	Cra g 1.0102	TKLEEAEKTASEAEQEI	Sequential / Linear	69-85	-	886612	IgE from pooled sera of Oyster allergic patients	-	-	Immunodominant epitope	ELISA	30807831	-
Cra g 1	Cra g 1.0102	MERSEERLQT	Sequential / Linear	99-108	-	886606	IgE from pooled sera of Oyster allergic patients	-	-	Immunodominant epitope	ELISA	30807831	-
Cra g 1	Cra g 1.0102	NNASEERTDVL	Sequential / Linear	134-144	-	886608	IgE from pooled sera of Oyster allergic patients	-	-	Immunodominant epitope	ELISA	30807831	-
Cra g 1	Cra g 1.0102	VQNDQASQREDSYEET	Sequential / Linear	209-224	-	886615	IgE from pooled sera of Oyster allergic patients	-	-	Immunodominant epitope	ELISA	30807831	-
Cra g 1	Cra g 1.0101	IQLLEEDMERSEER	Sequential / Linear	92-105	-	-	IgE from serum of subjects allergic to mollusks and crustaceans	-	-	-	ELISA	DOI:10.1111/j.1365-2621.1998.tb15672.x	-

IgE Antibody Data

No IgE Antibody Data Available

Cross-reactivity Data

Allergen	Cross-reactive Allergens	Reference
Cra g 1	Cra a Trp (View AllerBase Entry) Hal di Trp (View AllerBase Entry) Chla n Trp (View AllerBase Entry) Pat y Trp (View AllerBase Entry) Ven ph Trp (View AllerBase Entry) Sol st Trp (View AllerBase Entry) Lit v 1 (View AllerBase Entry) Scy p 1 (View AllerBase Entry)	35848932
Cra g 1	Buc mi Trp (View AllerBase Entry) Ana br Trp (View AllerBase Entry) Hal di Trp (View AllerBase Entry) Ful m Trp (View AllerBase Entry) Tur c 1 (View AllerBase Entry) Nep po Trp (View AllerBase Entry) Spi sa Trp (View AllerBase Entry) Tre ke Trp (View AllerBase Entry) Sol st Trp (View AllerBase Entry) Ven ph Trp (View AllerBase Entry)	DOI:10.1016/j.foodchem.2008.09.100