AllerBase Allergen Database

Data for Bos d 5

WHO/IUIS recognized Allergen

1 1 1 1 1 1 1 1 1

Completeness Index: Denotes availibility of data for the allergen in Binary format
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0: data not available

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AllerBase ID	AB_A_00354	Allergen Name	Bos d 5
Source Organism	Bos taurus (Cattle)	Kingdom	Animal
Biological Function/Role	Retinol-binding protein	Mode of Exposure	Ingestion

Assays/Methods used for Experimental Characterization (Read More)

: Data Available

: Data not Available

Biological assay / test	IgE assay / test	Physicochemical test	Cell-based assay
Basophil/Mast cell/Histamine Test (Reference/s)	EAST (Reference/s)	Chromatography (Reference/s)	Lymphocyte proliferation assay (Reference/s)
Bronchial Test	ELISA (Reference/s)	Isoelectrofocusing
Conjunctival Test	Crossed immunoelectrophoresis	Mass spectrometry (MS) (Reference/s)
Nasal Test	Fluorescence Immunoassay (Reference/s)	N-terminal sequencing/sequence analysis
Oral Test (Reference/s)	Immunochemiluminescent assay (Reference/s)
Passive Cutaneous Anaphylaxis (PCA)	ImmunoCAP Test (Reference/s)
Skin Test (Reference/s)	Microarray (Reference/s)
	Radio Immunoassay (Reference/s)
	RAST (Reference/s)
	Western/Immunoblot (Reference/s)

Isoallergen/Variant for Bos d 5:

Available

Isoallergen/Variant	Common Name	GenBank Nucleotide	NCBI Protein (GenPept)	UniProtKB	RCSB-PDB (Click on the PDB id to view structure)	ETR (Evolutionary Trace analysis Report)
Bos d 5.0101	Beta-lactoglobulin B	X14712.1 (View Sequence)	CAA32835.1 (View Sequence)	P02754 (View Sequence)	1B0O 1B8E 1BEB 1BSO 1BSQ 1BSY 1CJ5 1DV9 1GX8 1GX9 1GXA 1QG5 1UZ2 1YUP 2AKQ 2BLG 2GJ5 2Q2M 2Q2P 2Q39 2R56 3BLG 3KZA 3NPO 3NQ3 3NQ9 3PH5 3PH6 3UEU 3UEV 3UEW 3UEX 4DQ3 4DQ4 4GNY 4IB6 4IB7 4IB8 4IB9 4IBA 4KII 4LZU 4LZV 4Y0P 4Y0Q 4Y0R 5IO6 6FXB	1b0o 1b8e 1beb 1bso 1bsq 1bsy 1cj5 1dv9 1gx8 1gx9 1gxa 1qg5 1uz2 1yup 2akq 2blg 2gj5 2q2m 2q2p 2q39 2r56 3blg 3kza 3npo 3nq3 3nq9 3ph5 3ph6 3ueu 3uev 3uew 3uex 4dq3 4dq4 4gny 4ib6 4ib7 4ib8 4ib9 4iba 4kii 4lzu 4lzv 4y0p 4y0q 4y0r 5io6 6fxb

Sequence Analysis

BLAST
Pairwise alignment
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BLAST Nucleotide/Protein sequence of Allergen Bos d 5 with Nucleotide or Protein sequences in AllerBase:
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Cross-links to Allergen Databases

IUIS	IUIS-Allergen
Allergome	164
AllFam	AF015

IgE Epitope Data

Allergen	Isoallergen / Isoform	Epitope	Type of Epitope	Sequence Position	View on Structure	IEDB	Antibody Used	IMGT	AgAbDb Link	Nature of Epitope	Assay	Reference	Comment
Bos d 5	Bos d 5.0101	LIVTQTMKGLDIQKVA	Sequential / Linear	17-32	1B8E 1BSO 1BSQ 1BSY 1QG5 1UZ2 2BLG 2Q2M 2Q2P 2Q39 3BLG 3NPO 3UEV 3UEX 4DQ4 4IB7 4IB8 4IB9 4IBA 4Y0P 4Y0Q	-	IgE from serum of patients with cow's milk allergy	-	-	-	Western / Immunoblot	11729348	-
Bos d 5	Bos d 5.0101	LLDAQSAPLRVYVEELKP	Sequential / Linear	47-64	1B0O 1B8E 1BEB 1BSO 1BSQ 1BSY 1CJ5 1DV9 1GXA 1QG5 1UZ2 1YUP 2AKQ 2BLG 2GJ5 2Q2M 2Q2P 2Q39 2R56 3BLG 3KZA 3NPO 3PH5 3PH6 3UEU 3UEV 3UEW 3UEX 4DQ3 4DQ4 4GNY 4IB7 4IB8 4IB9 4IBA 4KII 4LZU 4LZV 4Y0P 4Y0Q 4Y0R	-	IgE from serum of patients with cow's milk allergy	-	-	-	Western / Immunoblot	11729348	-
Bos d 5	Bos d 5.0101	KPTPEGDLEILLQK	Sequential / Linear	63-76	1B0O 1B8E 1BEB 1BSO 1BSQ 1BSY 1CJ5 1DV9 1GXA 1QG5 1UZ2 1YUP 2AKQ 2BLG 2GJ5 2Q2M 2Q2P 2Q39 2R56 3BLG 3KZA 3NPO 3PH5 3PH6 3UEU 3UEV 3UEW 3UEX 4DQ3 4DQ4 4GNY 4IB7 4IB8 4IB9 4IBA 4KII 4LZU 4LZV 4Y0P 4Y0Q 4Y0R	-	IgE from serum of patients with cow's milk allergy	-	-	-	Western / Immunoblot	11729348	-
Bos d 5	Bos d 5.0101	AQKKIIAEKTKI	Sequential / Linear	83-94	1B0O 1B8E 1BEB 1BSO 1BSQ 1BSY 1CJ5 1DV9 1GXA 1QG5 1UZ2 1YUP 2AKQ 2BLG 2GJ5 2Q2M 2Q2P 2Q39 2R56 3BLG 3NPO 3PH5 3PH6 3UEU 3UEV 3UEW 3UEX 4DQ3 4DQ4 4GNY 4IB7 4IB8 4IB9 4IBA 4KII 4LZU 4LZV 4Y0P 4Y0Q 4Y0R	3985	IgE from serum of patients with cow's milk allergy	-	-	-	Western / Immunoblot	11729348	-
Bos d 5	Bos d 5.0101	KTKIPAVFKIDA	Sequential / Linear	91-102	1B0O 1B8E 1BEB 1BSO 1BSQ 1BSY 1CJ5 1DV9 1GXA 1QG5 1UZ2 1YUP 2AKQ 2BLG 2GJ5 2Q2M 2Q2P 2Q39 2R56 3BLG 3NPO 3PH5 3PH6 3UEU 3UEV 3UEW 3UEX 4DQ3 4DQ4 4GNY 4IB7 4IB8 4IB9 4IBA 4KII 4LZU 4LZV 4Y0P 4Y0Q 4Y0R	33732	IgE from serum of patients with cow's milk allergy	-	-	-	Western / Immunoblot	11729348	-
Bos d 5	Bos d 5.0101	EVDDEALEKFDKALKALP	Sequential / Linear	143-160	1B0O 1B8E 1BEB 1BSO 1BSQ 1BSY 1CJ5 1DV9 1GXA 1QG5 1UZ2 1YUP 2AKQ 2BLG 2GJ5 2Q2M 2Q2P 2Q39 2R56 3BLG 3NPO 3PH5 3PH6 3UEU 3UEV 3UEW 3UEX 4DQ3 4DQ4 4GNY 4IB7 4IB8 4IB9 4IBA 4KII 4LZU 4LZV 4Y0P 4Y0Q 4Y0R	-	IgE from serum of patients with cow's milk allergy	-	-	-	Western / Immunoblot	11729348	-
Bos d 5	Bos d 5.0101	KALPMHIRLSFNPTQL	Sequential / Linear	157-172	1B0O 1BEB 1BSO 1BSQ 1BSY 1CJ5 1DV9 1GXA 1UZ2 1YUP 2AKQ 2BLG 2GJ5 2Q2M 2Q39 2R56 3BLG 3NPO 3PH5 3PH6 3UEU 3UEV 3UEW 3UEX 4DQ3 4DQ4 4GNY 4IB7 4IB8 4IB9 4IBA 4KII 4LZU 4LZV 4Y0P 4Y0Q 4Y0R	-	IgE from serum of patients with cow's milk allergy	-	-	-	Western / Immunoblot	11729348	-
Bos d 5	Bos d 5.0101	RTPEVDDEALE	Sequential / Linear	140-150	1B0O 1B8E 1BEB 1BSO 1BSQ 1BSY 1CJ5 1DV9 1GXA 1QG5 1UZ2 1YUP 2AKQ 2BLG 2GJ5 2Q2M 2Q2P 2Q39 2R56 3BLG 3KZA 3NPO 3PH5 3PH6 3UEU 3UEV 3UEW 3UEX 4DQ3 4DQ4 4GNY 4IB7 4IB8 4IB9 4IBA 4KII 4LZU 4LZV 4Y0P 4Y0Q 4Y0R	56145	IgE from serum of patients with cow's milk allergy	-	-	-	Radio Immuno Assay	1720415	-
Bos d 5	Bos d 5.0101	34TWY36;59VEE61;K63;E71;L73;Q75;81ECAQKK86;141TPE143;169PT170;172LEEQ175;177HI178	Discontinuous/ Conformational	34-36;59-60;61;63;71;73;75;81-86;141-143;169-170;172-175;177-178	1B0O 1B8E 1BEB 1BSO 1BSQ 1BSY 1CJ5 1DV9 1GXA 1QG5 1UZ2 1YUP 2AKQ 2BLG 2GJ5 2Q2M 2Q2P 2Q39 2R56 3BLG 3KZA 3NPO 3PH5 3PH6 3UEU 3UEV 3UEW 3UEX 4DQ3 4DQ4 4GNY 4IB7 4IB8 4IB9 4IBA 4KII 4LZU 4LZV 4Y0P 4Y0Q 4Y0R	151535	IgE Fab Fragment from milk-allergic patient	IMGT/3Dstructure-DB	AgAbDb	-	Allergen-Antibody Complex Structure	17997967	-
Bos d 5	Bos d 5.0102	LQKWENDECAQKKIIAEKTK	Sequential / Linear	74-93	-	78201	IgE from serum of patients with cow's milk allergy	-	-	-	Microarray	18774394	-
Bos d 5	Bos d 5.0101	WENGECAQK	Sequential / Linear	77-85	4LZU	-	Serum from cow milk-allergic patient	-	-	-	Dot blot	36307246	-
Bos d 5	Bos d 5.0101	VLVLDTDYK	Sequential / Linear	108-116	4LZU	-	Serum from cow milk-allergic patient	-	-	-	Dot blot	36307246	-
Bos d 5	Bos d 5.0101	TPEVDDEALEK	Sequential / Linear	141-151	4LZU	-	Serum from cow milk-allergic patient	-	-	-	Dot blot	36307246	-
Bos d 5	Bos d 5.0101	TPEVDDEALEKFDK	Sequential / Linear	141-154	4LZU	-	Serum from cow milk-allergic patient	-	-	-	Dot blot	36307246	-
Bos d 5	Bos d 5.0101	ALPMHIR	Sequential / Linear	158-164	4LZU	-	Serum from cow milk-allergic patient	-	-	-	Dot blot	36307246	-

IgE Antibody Data

Antibody data

Allergen data

Antibody/ Chain Description	Clone/ Isolate	Antibody Source	IMGT	NCBI Protein (GenPept)	Broad Allergen Category	Allergen Id /Name	Material used for Sensitization	Allergic Disease	Antibody studied in	Reference
IgE Fab light chain	PDB:2R56	Homo sapiens	-	-	Food	Bos d 5	Milk	Not specified	Adult	17997967
IgE Fab heavy chain	PDB:2R56	Homo sapiens	-	-	Food	Bos d 5	Milk	Not specified	Adult	17997967

Cross-reactivity Data

Allergen	Cross-reactive Allergens	Reference
Bos d 5	Ran t BLG (View AllerBase Entry)	17039668
Bos d 5	Bos d 4 (View AllerBase Entry)	1720415