Database of 2313 Experimentally Validated Allergens
Data for Bos d 12
WHO/IUIS recognized Allergen

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0: data not available
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AllerBase IDAB_A_00350Allergen NameBos d 12
Source OrganismBos taurus (Cattle)KingdomAnimal
Biological Function/RoleMilk proteinMode of ExposureIngestion

Assays/Methods used for Experimental Characterization (Read More)

  :  Data Available    : Data not Available

Biological assay / test IgE assay / test Physicochemical test Cell-based assay
Basophil/Mast cell/Histamine Test  (Reference/s)EAST Chromatography  (Reference/s)Lymphocyte proliferation assay  (Reference/s)
Bronchial Test ELISA  (Reference/s)Isoelectrofocusing 
Conjunctival Test Crossed immunoelectrophoresis Mass spectrometry (MS)  (Reference/s)
Nasal Test Fluorescence Immunoassay N-terminal sequencing/sequence analysis 
Oral Test Immunochemiluminescent assay 
Passive Cutaneous Anaphylaxis (PCA) ImmunoCAP Test 
Skin Test Microarray  (Reference/s)
Radio Immunoassay 
RAST 
Western/Immunoblot  (Reference/s)

Isoallergen/Variant for Bos d 12:Available

Isoallergen/Variant Common Name GenBank Nucleotide NCBI Protein (GenPept) UniProtKB RCSB-PDB (Click on the PDB id to view structure) ETR (Evolutionary Trace analysis Report)
Bos d 12.0101Kappa-casein
NM_174294  (View Sequence)NP_776719  (View Sequence)P02668  (View Sequence)
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Sequence Analysis

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  • BLAST Nucleotide/Protein sequence of Allergen Bos d 12 with Nucleotide or Protein sequences in AllerBase:
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Cross-links to Allergen Databases

IUISIUIS-Allergen
Allergome2737
AllFamAF085

IgE Epitope Data

Allergen Isoallergen / Isoform Epitope Type of Epitope Sequence Position View on Structure IEDB Antibody Used IMGT AgAbDb Link Nature of Epitope Assay Reference Comment
Bos d 12Bos d 12.0101IRCEKDERFFSDKIAKYISequential / Linear30-47--IgE from serum of children with cow's milk allergy--Major epitopeWestern / Immunoblot11529896-
Bos d 12Bos d 12.0101KIAKYIPIQYVLSRYPSYGLNYYQSequential / Linear42-65--IgE from serum of children with cow's milk allergy--Major epitopeWestern / Immunoblot11529896-
Bos d 12Bos d 12.0101PVALINNQFLPYPYYAKPAAVRSequential / Linear68-89--IgE from serum of children with cow's milk allergy--Major epitopeWestern / Immunoblot11529896-
Bos d 12Bos d 12.0101VRSPAQILQWQVSequential / Linear88-99--IgE from serum of children with cow's milk allergy--Major epitopeWestern / Immunoblot11529896-
Bos d 12Bos d 12.0101MARHPHPHLSFMAIPPKKNQDKSequential / Linear116-137--IgE from serum of children with cow's milk allergy--Major epitopeWestern / Immunoblot11529896-
Bos d 12Bos d 12.0101PHLSFMAIPPKKNQDKTEIPTINTIASequential / Linear122-147--IgE from serum of children with cow's milk allergy--Major epitopeWestern / Immunoblot11529896-
Bos d 12Bos d 12.0101EAVESTVATLEDSequential / Linear158-169--IgE from serum of children with cow's milk allergy--Major epitopeWestern / Immunoblot11529896-
Bos d 12Bos d 12.0101SPEVIESPPEINTVQVTSSequential / Linear170-187--IgE from serum of children with cow's milk allergy--Major epitopeWestern / Immunoblot11529896-
Bos d 12Bos d 12.0101KDERFFSDKISequential / Linear34-43-30141IgE from serum of patients with persistent cow's milk allergy---Western / Immunoblot12170271-
Bos d 12Bos d 12.0101SPPEINTVQVSequential / Linear176-185-60178IgE from serum of patients with persistent cow's milk allergy---Western / Immunoblot12170271-
Bos d 12Bos d 12.0101RYPSYGLNYYQQKPVALINNSequential / Linear55-74-78267IgE from serum of patients with cow's milk allergy---Microarray18774394-

IgE Antibody Data


No IgE Antibody Data Available

Cross-reactivity Data


No Cross-Reactivity Data Available