Database of 2313 Experimentally Validated Allergens
Data for Bet v 2
WHO/IUIS recognized Allergen

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Completeness Index: Denotes availibility of data for the allergen in Binary format
1: data available
0: data not available
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AllerBase IDAB_P_00291Allergen NameBet v 2
Source OrganismBetula pendula (European white birch)KingdomPlant
Biological Function/RoleActin-binding proteinMode of ExposureInhalation

Assays/Methods used for Experimental Characterization (Read More)

  :  Data Available    : Data not Available

Biological assay / test IgE assay / test Physicochemical test Cell-based assay
Basophil/Mast cell/Histamine Test  (Reference/s)EAST  (Reference/s)Chromatography  (Reference/s)Lymphocyte proliferation assay  (Reference/s)
Bronchial Test  (Reference/s)ELISA  (Reference/s)Isoelectrofocusing 
Conjunctival Test Crossed immunoelectrophoresis Mass spectrometry (MS)  (Reference/s)
Nasal Test Fluorescence Immunoassay  (Reference/s)N-terminal sequencing/sequence analysis 
Oral Test Immunochemiluminescent assay 
Passive Cutaneous Anaphylaxis (PCA) ImmunoCAP Test  (Reference/s)
Skin Test  (Reference/s)Microarray  (Reference/s)
Radio Immunoassay 
RAST  (Reference/s)
Western/Immunoblot  (Reference/s)

Isoallergen/Variant for Bet v 2:Available

Isoallergen/Variant Common Name GenBank Nucleotide NCBI Protein (GenPept) UniProtKB RCSB-PDB (Click on the PDB id to view structure) ETR (Evolutionary Trace analysis Report)
Bet v 2.0101Profilin-1
M65179.1  (View Sequence)AAA16522.1  (View Sequence)P25816  (View Sequence)
1CQA 5NZB 5NZC 
1cqa  5nzb  5nzc  

Sequence Analysis

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Cross-links to Allergen Databases

IUISIUIS-Allergen
Allergome127
AllFamAF051

IgE Epitope Data

Allergen Isoallergen / Isoform Epitope Type of Epitope Sequence Position View on Structure IEDB Antibody Used IMGT AgAbDb Link Nature of Epitope Assay Reference Comment
Bet v 2Bet v 2.0101PQFKPQSequential / Linear42-471CQA  48996Monoclonal antibody 4A6IMGT/3Dstructure-DB--Western blot8939935Monoclonal antibody from Mouse
Bet v 2Bet v 2.0101MSWQTYVDEHLMCDIDGQGEELAASAIVGHDGSequential / Linear1-32-78467IgE from serum of profilin-allergic patients--Major epitopePhage display / Immunopanning9016715-
Bet v 2Bet v 2.0101VGHDGSVWAQSSSFPQFKPQSequential / Linear28-471CQA  78553IgE from serum of profilin-allergic patients--Major epitopePhage display / Immunopanning9016715-
Bet v 2Bet v 2.0101VWAQSSSFPQFKPQESequential / Linear34-481CQA  78561IgE from serum of profilin-allergic patients--Major epitopePhage display / Immunopanning9016715-
Bet v 2Bet v 2.0101AQSSSFPQFKPQEITGISequential / Linear36-521CQA  78351IgE from serum of profilin-allergic patients--Major epitopePhage display / Immunopanning9016715-
Bet v 2Bet v 2.0101IYEEPVTPGQCNMVVERLGDYLIDQGLSequential / Linear107-1331CQA  78427IgE from serum of profilin-allergic patients--Major epitopePhage display / Immunopanning9016715-

IgE Antibody Data

Antibody data Allergen data
Antibody/ Chain Description Clone/ Isolate Antibody Source IMGT NCBI Protein (GenPept) Broad Allergen Category Allergen Id /Name Material used for Sensitization Allergic Disease Antibody studied in Reference
Monoclonal antibody 4A6, heavy chain-Mus musculusY08364-RespiratoryBet v 2Birch profilinNot specifiedNot specified8939935
Monoclonal antibody 4A6, light chain-Mus musculusY08365CAA69651.1RespiratoryBet v 2Birch profilinNot specifiedNot specified8939935

Cross-reactivity Data

Allergen Cross-reactive Allergens Reference
Bet v 2Gly m 3   (View AllerBase Entry)10589015
Bet v 2Api g 4   (View AllerBase Entry)10848918
Bet v 2Api g 4  (View AllerBase Entry)
Pru av 4  (View AllerBase Entry)
Pyr c 4  (View AllerBase Entry)
11419723
Bet v 2Hev b 8  (View AllerBase Entry)
Mus a 1  (View AllerBase Entry)
Ana c 1  (View AllerBase Entry)
12065910
Bet v 2Pru p 4   (View AllerBase Entry)12823124
Bet v 2Bra n PFN   (View AllerBase Entry)14600423
Bet v 2Par j 3  (View AllerBase Entry)
Phl p 12  (View AllerBase Entry)
14739580
Bet v 2Sola l 1   (View AllerBase Entry)15080834
Bet v 2Cit s 2   (View AllerBase Entry)16197476
Bet v 2Man i 3   (View AllerBase Entry)17417721
Bet v 2Hom s PFN   (View AllerBase Entry)1857985
Bet v 2Que a PFN   (View AllerBase Entry)18754759
Bet v 2Fag s 2   (View AllerBase Entry)18754759
Bet v 2Cuc m 2  (View AllerBase Entry)
Phl p 12  (View AllerBase Entry)
20205701
Bet v 2Ara h 5  (View AllerBase Entry)
Phl p 12  (View AllerBase Entry)
20230899
Bet v 2Pla l 2  (View AllerBase Entry)
Phl p 12  (View AllerBase Entry)
28126622
Bet v 2Sola m 1   (View AllerBase Entry)31901836
Bet v 2Amb a 8  (View AllerBase Entry)
Phl p 12  (View AllerBase Entry)
Art v 4  (View AllerBase Entry)
36835455
Bet v 2Art v 4  (View AllerBase Entry)
Api g 4  (View AllerBase Entry)
8911702
Bet v 2Phl p 1  (View AllerBase Entry)
Phl p 2  (View AllerBase Entry)
Phl p 5  (View AllerBase Entry)
9500760
Bet v 2Lit c 1   (View AllerBase Entry)DOI:10.1080/09540100701616290