AllerBase Allergen Database

Data for Ara h 2

WHO/IUIS recognized Allergen

1 1 1 1 1 1 1 1 1

Completeness Index: Denotes availibility of data for the allergen in Binary format
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0: data not available

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AllerBase ID	AB_P_00173	Allergen Name	Ara h 2
Source Organism	Arachis hypogaea (Peanut)	Kingdom	Plant
Biological Function/Role	2S albumin	Mode of Exposure	Ingestion

Assays/Methods used for Experimental Characterization (Read More)

: Data Available

: Data not Available

Biological assay / test	IgE assay / test	Physicochemical test	Cell-based assay
Basophil/Mast cell/Histamine Test (Reference/s)	EAST (Reference/s)	Chromatography (Reference/s)	Lymphocyte proliferation assay (Reference/s)
Bronchial Test	ELISA (Reference/s)	Isoelectrofocusing
Conjunctival Test	Crossed immunoelectrophoresis	Mass spectrometry (MS) (Reference/s)
Nasal Test	Fluorescence Immunoassay (Reference/s)	N-terminal sequencing/sequence analysis (Reference/s)
Oral Test	Immunochemiluminescent assay
Passive Cutaneous Anaphylaxis (PCA)	ImmunoCAP Test (Reference/s)
Skin Test (Reference/s)	Microarray (Reference/s)
	Radio Immunoassay
	RAST (Reference/s)
	Western/Immunoblot (Reference/s)

Isoallergen/Variant for Ara h 2:

Available

Isoallergen/Variant	Common Name	GenBank Nucleotide	NCBI Protein (GenPept)	UniProtKB	RCSB-PDB (Click on the PDB id to view structure)	ETR (Evolutionary Trace analysis Report)
Ara h 2.0101	Conglutin-7	AY007229.1 (View Sequence)	AAK96887.1 (View Sequence)	Q6PSU2 (View Sequence)	8DB4	8db4
Ara h 2.0201	Conglutin-7	AY158467.1 (View Sequence)	AAN77576.1 (View Sequence)	Q6PSU2 (View Sequence)	-	-

Sequence Analysis

BLAST
Pairwise alignment
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BLAST Nucleotide/Protein sequence of Allergen Ara h 2 with Nucleotide or Protein sequences in AllerBase:
Select GenBank or UniprotKB accession number by clicking on the checkbox in the above table

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Align Nucleotode/Protein sequence of Your choice with Nucleotode or Protein sequence of Allergen Ara h 2: (Alignment job will be redirected to EMBL-EMBOSS Water or Needle tool)

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Cross-links to Allergen Databases

IUIS	IUIS-Allergen
Allergome	51
AllFam	AF050

IgE Epitope Data

Allergen	Isoallergen / Isoform	Epitope	Type of Epitope	Sequence Position	View on Structure	IEDB	Antibody Used	IMGT	AgAbDb Link	Nature of Epitope	Assay	Reference	Comment
Ara h 2	Ara h 2.0101	RDPYSPSQDPYSPS	Sequential / Linear	62-75	-	157833	IgE from Peanut-allergic patients	-	-	-	Western / Immunoblot	21883278	-
Ara h 2	Ara h 2.0101	EDSYERDPYSPSQDPY	Sequential / Linear	57-72	-	2151233	IgE from Peanut-allergic patients	-	-	-	Dot blot	36527758	-
Ara h 2	Ara h 2.0101	PYSPSQDPYSPSPYDR	Sequential / Linear	64-79	-	2151250	IgE from Peanut-allergic patients	-	-	-	Dot blot	36527758	-
Ara h 2	Ara h 2.0101	DRRGAGSSQHQERCCN	Sequential / Linear	90-105	-	2151232	IgE from Peanut-allergic patients	-	-	-	Dot blot	36527758	-
Ara h 2	Ara h 2.0101	ENNQRCMCEALQQIME	Sequential / Linear	111-126	-	2151235	IgE from Peanut-allergic patients	-	-	-	Dot blot	36527758	-
Ara h 2	Ara h 2.0101	QQFKRELRNLPQQCGL	Sequential / Linear	139-154	-	2151253	IgE from Peanut-allergic patients	-	-	-	Dot blot	36527758	-
Ara h 2	Ara h 2.0101	HASARQQWEL	Sequential / Linear	18-27	-	23562	IgE from serum of peanut allergic patients	-	-	-	Western / Immunoblot	9186485	-
Ara h 2	Ara h 2.0101	QWELQGDR	Sequential / Linear	24-31	-	52829	IgE from serum of peanut allergic patients	-	-	-	Western / Immunoblot	9186485	-
Ara h 2	Ara h 2.0101	DRRCQSQLER	Sequential / Linear	30-39	-	10040	IgE from serum of peanut allergic patients	-	-	Immunodominant epitope	Western / Immunoblot	9186485	-
Ara h 2	Ara h 2.0101	LRPCEQHLMQ	Sequential / Linear	42-51	-	39156	IgE from serum of peanut allergic patients	-	-	-	Western / Immunoblot	9186485	-
Ara h 2	Ara h 2.0101	KIQRDEDS	Sequential / Linear	52-59	-	31404	IgE from serum of peanut allergic patients	-	-	-	Western / Immunoblot	9186485	-
Ara h 2	Ara h 2.0101	RDPYSP	Sequential / Linear	62-67	-	73754	IgE from serum of peanut allergic patients	-	-	Immunodominant epitope	Western / Immunoblot	9186485	-
Ara h 2	Ara h 2.0101	SQDPYSPS	Sequential / Linear	68-75	-	60413	IgE from serum of peanut allergic patients	-	-	Immunodominant epitope	Western / Immunoblot	9186485	-
Ara h 2	Ara h 2.0101	LQGRQQ	Sequential / Linear	120-125	-	10012	IgE from serum of peanut allergic patients	-	-	-	Western / Immunoblot	9186485	-
Ara h 2	Ara h 2.0101	KRELRN	Sequential / Linear	130-135	-	33122	IgE from serum of peanut allergic patients	-	-	-	Western / Immunoblot	9186485	-
Ara h 2	Ara h 2.0101	QRCDLDVE	Sequential / Linear	146-153	-	52191	IgE from serum of peanut allergic patients	-	-	-	Western / Immunoblot	9186485	-

IgE Antibody Data

Antibody data

Allergen data

Antibody/ Chain Description	Clone/ Isolate	Antibody Source	IMGT	NCBI Protein (GenPept)	Broad Allergen Category	Allergen Id /Name	Material used for Sensitization	Allergic Disease	Antibody studied in	Reference
13T1 light chain	PDB:8DB4	Homo sapiens	-	-	Food	Ara h 2	Ara h 2	Not specified	Not specified	36647835
13T1 heavy chain	PDB:8DB4	Homo sapiens	-	-	Food	Ara h 2	Ara h 2	Not specified	Not specified	36647835
22S1 light chain	PDB:8DB4	Homo sapiens	-	-	Food	Ara h 2	Ara h 2	Not specified	Not specified	36647835
22S1 heavy chain	PDB:8DB4	Homo sapiens	-	-	Food	Ara h 2	Ara h 2	Not specified	Not specified	36647835

Cross-reactivity Data

Allergen	Cross-reactive Allergens	Reference
Ara h 2	Ara h 6 (View AllerBase Entry)	15836759
Ara h 2	Lup an DCong (View AllerBase Entry) Lup an ACong (View AllerBase Entry)	19639724
Ara h 2	Ara h 3 (View AllerBase Entry) Ara h 1 (View AllerBase Entry)	23465659
Ara h 2	Ara h 1 (View AllerBase Entry) Ara h 3 (View AllerBase Entry) Ara h 6 (View AllerBase Entry)	25802736
Ara h 2	Ara h 1 (View AllerBase Entry) Ara h 3 (View AllerBase Entry)	30545888