AllerBase Allergen Database

Data for Ani s 1

WHO/IUIS recognized Allergen

1 1 1 1 1 0 1 0 0

Completeness Index: Denotes availibility of data for the allergen in Binary format
1: data available
0: data not available

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AllerBase ID	AB_A_00111	Allergen Name	Ani s 1
Source Organism	Anisakis simplex (Herring worm)	Kingdom	Animal
Biological Function/Role	Serine protease inhibitor	Mode of Exposure	Ingestion

Assays/Methods used for Experimental Characterization (Read More)

: Data Available

: Data not Available

Biological assay / test	IgE assay / test	Physicochemical test	Cell-based assay
Basophil/Mast cell/Histamine Test (Reference/s)	EAST (Reference/s)	Chromatography (Reference/s)	Lymphocyte proliferation assay (Reference/s)
Bronchial Test	ELISA (Reference/s)	Isoelectrofocusing
Conjunctival Test	Crossed immunoelectrophoresis	Mass spectrometry (MS) (Reference/s)
Nasal Test	Fluorescence Immunoassay	N-terminal sequencing/sequence analysis (Reference/s)
Oral Test	Immunochemiluminescent assay
Passive Cutaneous Anaphylaxis (PCA)	ImmunoCAP Test
Skin Test (Reference/s)	Microarray (Reference/s)
	Radio Immunoassay
	RAST
	Western/Immunoblot (Reference/s)

Isoallergen/Variant for Ani s 1:

Available

Isoallergen/Variant	Common Name	GenBank Nucleotide	NCBI Protein (GenPept)	UniProtKB	RCSB-PDB (Click on the PDB id to view structure)	ETR (Evolutionary Trace analysis Report)
Ani s 1.0101	Major allergen Ani s 1	AB100095.1 (View Sequence)	BAC77154.1 (View Sequence)	Q7Z1K3 (View Sequence)	-	-

Sequence Analysis

BLAST
Pairwise alignment
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BLAST Nucleotide/Protein sequence of Allergen Ani s 1 with Nucleotide or Protein sequences in AllerBase:
Select GenBank or UniprotKB accession number by clicking on the checkbox in the above table

Default E-value cut-off for BLAST is set at 0.01.

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Align Nucleotode/Protein sequence of Your choice with Nucleotode or Protein sequence of Allergen Ani s 1: (Alignment job will be redirected to EMBL-EMBOSS Water or Needle tool)

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Cross-links to Allergen Databases

IUIS	IUIS-Allergen
Allergome	35
AllFam	AF003

IgE Epitope Data

Allergen

Isoallergen / Isoform

Epitope

Type of Epitope

Sequence Position

View on Structure

IEDB

Antibody Used

IMGT

AgAbDb Link

Nature of Epitope

Assay

Reference

Comment

Ani s 1

Ani s 1.0101

ELFAREYEGVCKSGK

Sequential / Linear

139-153

137145

IgE from serum of Anisakis-allergic patients

Major epitope

Fluorescence ELISA

20655337

Ani s 1

Ani s 1.0101

RGSGWMMTILGKSCD

Sequential / Linear

159-173

137278

IgE from serum of Anisakis-allergic patients

Major epitope

Fluorescence ELISA

20655337

IgE Antibody Data

Antibody data

Allergen data

Antibody/ Chain Description	Clone/ Isolate	Antibody Source	IMGT	NCBI Protein (GenPept)	Broad Allergen Category	Allergen Id /Name	Material used for Sensitization	Allergic Disease	Antibody studied in	Reference
Monoclonal antibody 4E8g	-	Mus musculus	-	-	Food	Ani s 13	Anisakis extract	Not specified	Not specified	24009787

Cross-reactivity Data

No Cross-Reactivity Data Available