References/Publications for ELISA of Mal d 1

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7549498 Int Arch Allergy Immunol. 1995 Oct;108(2):119-26.

Purification and characterization of the major allergen from apple and its
allergenic cross-reactivity with Bet v 1.

Fahlbusch B(1), Rudeschko O, Müller WD, Schlenvoigt G, Vettermann S, Jäger L.

9042050 J Allergy Clin Immunol. 1997 Feb;99(2):227-32.

Biologic allergen assay for in vivo test allergens with an in vitro model of the
murine type I reaction.

Hoffmann A(1), Vieths S, Haustein D.

16293967 Int Arch Allergy Immunol. 2006;139(1):53-62. Epub 2005 Nov 15.

Mutational analysis of amino acid positions crucial for IgE-binding epitopes of
the major apple (Malus domestica) allergen, Mal d 1.

Ma Y(1), Gadermaier G, Bohle B, Bolhaar S, Knulst A, Markovic-Housley Z,
Breiteneder H, Briza P, Hoffmann-Sommergruber K, Ferreira F.

16752695 Eur Ann Allergy Clin Immunol. 2006 Mar;38(3):94-8.

Search for low-allergenic apple cultivars for birch-pollen-allergic patients: is
there a correlation between in vitro assays and patient response?

Asero R(1), Marzban G, Martinelli A, Zaccarini M, Machado ML.

16881695 J Agric Food Chem. 2006 Aug 9;54(16):5917-23.

Effect of postharvest storage on the expression of the apple allergen Mal d 1.

Sancho AI(1), Foxall R, Browne T, Dey R, Zuidmeer L, Marzban G, Waldron KW, van
Ree R, Hoffmann-Sommergruber K, Laimer M, Mills EN.

18450119 Ann Allergy Asthma Immunol. 2008 Apr;100(4):338-42. doi:

Effect of Lactobacillus rhamnosus GG on rBet v1 and rMal d1 specific IgA in the
saliva of patients with birch pollen allergy.

Piirainen L(1), Haahtela S, Helin T, Korpela R, Haahtela T, Vaarala O.

18683825 Mol Nutr Food Res. 2008 Nov;52 Suppl 2:S208-19. doi: 10.1002/mnfr.200700522.

Purification and characterisation of relevant natural and recombinant apple

Oberhuber C(1), Ma Y, Marsh J, Rigby N, Smole U, Radauer C, Alessandri S, Briza
P, Zuidmeer L, Maderegger B, Himly M, Sancho AI, van Ree R, Knulst A, Ebner C,
Shewry P, Mills EN, Wellner K, Breiteneder H, Hoffmann-Sommergruber K, Bublin M.

19154550 Allergy. 2009 Apr;64(4):647-51. doi: 10.1111/j.1398-9995.2008.01844.x. Epub 2009
Jan 9.

Identification of B-cell epitopes of Bet v 1 involved in cross-reactivity with
food allergens.

Klinglmayr E(1), Hauser M, Zimmermann F, Dissertori O, Lackner P, Wopfner N,
Ferreira F, Wallner M.

19845340 J Agric Food Chem. 2009 Nov 25;57(22):10548-53. doi: 10.1021/jf901938q.

Apple (Malus domestica L. Borkh.) allergen Mal d 1: effect of cultivar,
cultivation system, and storage conditions.

Matthes A(1), Schmitz-Eiberger M.

20557297 Allergy. 2010 Nov;65(11):1388-96. doi: 10.1111/j.1398-9995.2010.02407.x.

Bet v 1 and its homologous food allergen Api g 1 stimulate dendritic cells from
birch pollen-allergic individuals to induce different Th-cell polarization.

Smole U(1), Wagner S, Balazs N, Radauer C, Bublin M, Allmaier G,
Hoffmann-Sommergruber K, Breiteneder H.

21984443 Mol Nutr Food Res. 2011 Oct;55(10):1484-91. doi: 10.1002/mnfr.201100234. Epub
2011 Aug 30.

A food matrix reduces digestion and absorption of food allergens in vivo.

Schulten V(1), Lauer I, Scheurer S, Thalhammer T, Bohle B.

23578620 Food Chem. 2013 Sep 1;140(1-2):99-104. doi: 10.1016/j.foodchem.2013.02.045. Epub
2013 Feb 22.

The impact of catechin and epicatechin, total phenols and PPO activity on the Mal
d 1 content in apple fruit.

Kiewning D(1), Wollseifen R, Schmitz-Eiberger M.

24130074 J Sci Food Agric. 2014 Mar 15;94(4):798-802. doi: 10.1002/jsfa.6448. Epub 2013
Nov 11.

Effects of long-term storage on Mal d 1 content of four apple cultivars with
initial low Mal d 1 content.

Kiewning D(1), Schmitz-Eiberger M.

24224690 Allergy. 2014 Feb;69(2):208-15. doi: 10.1111/all.12306. Epub 2013 Nov 14.

Differences in the intrinsic immunogenicity and allergenicity of Bet v 1 and
related food allergens revealed by site-directed mutagenesis.

Roulias A(1), Pichler U, Hauser M, Himly M, Hofer H, Lackner P, Ebner C, Briza P,
Bohle B, Egger M, Wallner M, Ferreira F.

26013405 BMC Biotechnol. 2015 May 27;15:34. doi: 10.1186/s12896-015-0157-5.

Isolation of Mal d 1 and Api g 1 - specific recombinant antibodies from mouse IgG
Fab fragment libraries - Mal d 1-specific antibody exhibits cross-reactivity
against Bet v 1.

Haka J(1), Niemi MH(2), Iljin K(3), Reddy VS(4), Takkinen K(5), Laukkanen ML(6).

27376790 Clin Exp Allergy. 2016 Nov;46(11):1474-1483. doi: 10.1111/cea.12775. Epub 2016
Aug 8.

Birch pollen immunotherapy inhibits anaphylaxis to the cross-reactive apple
allergen Mal d 1 in mice.

Utsch L(1), Logiantara A(2), Wallner M(3), Hofer H(3), van Ree R(2)(4), van Rijt

J Allergy Clin Immunol. 2020 Oct;146(4):894-900.e2. doi:
1016/j.jaci.2020.03.015. Epub 2020 Apr 4.

IgE-blocking antibodies following SLIT with recombinant Mal d 1 accord with
improved apple allergy.

Sánchez Acosta G(1), Kinaciyan T(2), Kitzmüller C(1), Möbs C(3), Pfützner W(3),
Bohle B(4).

Sci Rep. 2020 Jun 4;10(1):9144. doi: 10.1038/s41598-020-66051-4.

Tiered approach for the identification of Mal d 1 reduced, well tolerated apple

Romer E(1), Chebib S(1), Bergmann KC(2), Plate K(3), Becker S(4), Ludwig C(5),
Meng C(5), Fischer T(6), Dierend W(3), Schwab W(7).

33013894 Front Immunol. 2020 Sep 3;11:2118. doi: 10.3389/fimmu.2020.02118. eCollection

In vivo Induction of Functional Inhibitory IgG Antibodies by a Hypoallergenic Bet
v 1 Variant.

Aglas L(1), Bethanis A(1), Chrusciel P(2), Stolz F(3), Gruen M(1), Jaakkola
UM(2), Jongejan L(4), Yatkin E(2), Van Ree R(4).

33946582 Molecules. 2021 Apr 30;26(9). pii: 2647. doi: 10.3390/molecules26092647.

Relationship between Phenolic Compounds, Antioxidant Properties, and the
Allergenic Protein Mal d 1 in Different Selenium-Biofortified Apple Cultivars
(Malus domestica).

Groth S(1), Budke C(2), Weber T(2), Neugart S(3), Brockmann S(1), Holz M(1),
Sawadski BC(1), Daum D(2), Rohn S(1)(4).