| Select | PubMed ID | Description |
| 6747135 | J Allergy Clin Immunol. 1984 Aug;74(2):147-53.
Cat allergen 1: Biochemical, antigenic, and allergenic properties.
Leitermann K, Ohman JL Jr.
Cat allergen 1, an important agent in human allergic reactions, has been
partially purified by affinity chromatography. Heating the purified allergen at
100 degrees C for 30 min resulted in a 28% loss in the antigenicity of the
allergen molecule (determined by Laurell rocket assay), although lower
temperatures had little effect. Its allergenicity (determined by passive transfer
skin test) was diminished slightly after heating to 56 degrees C or 100 degrees
C. Reduction with dithiothreitol or 2-mercaptoethanol resulted in greater losses
of antigenicity and allergenicity but did not obliterate these properties. Three
forms of the affinity-purified allergen (isoallergens) differing slightly in
isoelectric point were demonstrated by isoelectric focusing followed by crossed
immunoelectrophoresis. The molecular weight of cat allergen 1 under physiologic
conditions was 35,000 +/- 2000 as determined by gel filtration in Sephadex G-75.
Under the dissociative conditions of sodium dodecyl sulfate-polyacrylamide gel
electrophoresis, with or without prior reduction by dithiothreitol, cat allergen
1 appeared to exist as an antigenically active subunit with a molecular weight of
18,000 +/- 2000. This subunit molecular weight estimate was confirmed by gel
filtration in 6M guanidine hydrochloride. The stability of the allergenic and
antigenic activity of cat allergen 1 suggests that this activity may be
determined partially by the primary sequence of allergenic sites on the molecule.
The separation and purification of molecular subunits may allow sequence analysis
of these sites.
PMID: 6747135 [Indexed for MEDLINE]
|
| 7573835 |
Allergy. 1995 May;50(5):447-50.
Etiologic role of unapparent exposure in cat allergy.
Brasó-Aznar JV(1), Pelaez-Hernandez A, Rochina-Puchades A, Morales-Rubio C,
Burches Baixauli E.
|
| 7680928 | Int Arch Allergy Immunol. 1993;100(3):256-62.
Role of the major allergen (Fel d I) in patients sensitized to cat allergens.
Kleine-Tebbe J(1), Kleine-Tebbe A, Jeep S, Schou C, Løwenstein H, Kunkel G.
|
| 8151058 | J Allergy Clin Immunol. 1994 Mar;93(3):556-66.
Monoclonal antibody-standardized cat extract immunotherapy: risk-benefit effects
from a double-blind placebo study.
Alvarez-Cuesta E(1), Cuesta-Herranz J, Puyana-Ruiz J, Cuesta-Herranz C,
Blanco-Quirós A.
|
| 8634522 | Int Arch Allergy Immunol. 1996 Apr;109(4):369-75.
Fel d 1-specific IgG antibodies induced by natural exposure have blocking
activity in skin tests.
Witteman AM(1), Stapel SO, Sjamsoedin DH, Jansen HM, Aalberse RC, van der Zee JS.
|
| 8982778 | Int Immunol. 1996 Dec;8(12):1937-45.
Fel d 1 peptides: effect on skin tests and cytokine synthesis in cat-allergic
human subjects.
Simons FE(1), Imada M, Li Y, Watson WT, HayGlass KT.
|
| 10410917 | Pediatr Allergy Immunol. 1999 Feb;10(1):45-52.
Markers of inflammation and bronchial reactivity in children with asthma, exposed
to animal dander in school dust.
Lönnkvist K(1), Halldén G, Dahlén SE, Enander I, van Hage-Hamsten M, Kumlin M,
Hedlin G.
|
| 10624493 | Allergy Asthma Proc. 1999 Nov-Dec;20(6):371-6.
Correlation of cat-hair (Fel d1) prick skin test to airway response using a
live-cat-room challenge model.
Wanger JS(1), Dockhorn RJ.
|
| 11991555 | Ann Allergy Asthma Immunol. 2002 Apr;88(4):374-9.
A comparison of two skin test methodologies and allergens from two different
manufacturers.
Rhodius R(1), Wickens K, Cheng S, Crane J.
|
| 17575100 | Am J Respir Crit Care Med. 2007 Sep 1;176(5):446-53. Epub 2007 Jun 15.
Early-life allergen exposure and atopy, asthma, and wheeze up to 6 years of age.
Torrent M(1), Sunyer J, Garcia R, Harris J, Iturriaga MV, Puig C, Vall O, Anto
JM, Newman Taylor AJ, Cullinan P.
|
| 19486030 | Clin Exp Allergy. 2009 Oct;39(10):1515-21. doi: 10.1111/j.1365-2222.2009.03288.x.
Epub 2009 May 26.
Cat sensitization according to cat window of exposure in adult asthmatics.
Oryszczyn MP(1), Van Ree R, Maccario J, Nadif R, Kauffmann F; EGEA cooperative
group.
Collaborators: Kauffmann F, Demenais F, Pin I, Korobaeff M, Neukirch F,
Annesi-Maesano I, Le Moual N, Nadif R, Oryszczyn MP, Siroux V, Feingold J, Dizier
MH, Bouzigon E, Demenais F, Gut I, Lathrop M, Pison C, Ecochard D, Gormand F,
Pacheco Y, Charpin D, Vervloet D, Bousquet J, Lockhart A, Matran R, Paty E,
Scheinmann P, Grimfeld A, Just J, Hochez J, Le Moual N, Ravault C, Chateigner N,
Ferran J.
|
| 20804464 | Allergy. 2011 Feb;66(2):255-63. doi: 10.1111/j.1398-9995.2010.02468.x. Epub 2010
Aug 30.
Treatment with a Fel d 1 hypoallergen reduces allergic responses in a mouse model
for cat allergy.
Saarne T(1), Neimert-Andersson T, Grönlund H, Jutel M, Gafvelin G, van Hage M.
|
| 24726651 | Ann Allergy Asthma Immunol. 2014 Jun;112(6):545-550.e1. doi:
1016/j.anai.2014.03.007. Epub 2014 Apr 13.
Changes in cat specific IgE and IgG antibodies with decreased cat exposure.
Erwin EA(1), Woodfolk JA(2), James HR(2), Satinover SM(2), Platts-Mills TA(2).
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